This hard-wired injury detection mode for pain is called "nociception", meaning detection of harm, while the nerves which detect the damage are called nociceptor nerves ( "nociceptors" for short). From Wordnik.com. [Citizendium, the Citizens' Compendium - Recent changes [en]] Reference
Such nociceptor activation, for example, was first shown in vivo in fetal rats 25. From Wordnik.com. [Morality is Objective (And People Are Wrong)] Reference
Activity induced in the nociceptor and nociceptive pathways by a noxious stimulus is not pain, which is always a psychological state, even though we may well appreciate that pain most often has a proximate physical cause. From Wordnik.com. [Pain] Reference
Kanui TI (1985) Thermal inhibition of nociceptor-driven spinal cord neurones in the rat. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
LLLT also enables one to suppress the action of nociceptor along with increasing serotonin production. From Wordnik.com. [WN.com - Articles related to Scientists uncover mysterious workings of cholera bacteria] Reference
Slide 9: Introduction Bone metastases can generate pain by - A strong mechanical impact to the nociceptor. From Wordnik.com. [Recently Uploaded Slideshows] Reference
Under such conditions, descending pathways travel through the thalamus and inhibit nociceptor neurons in the spinal cord (1). From Wordnik.com. [Serendip's Exchange -] Reference
The effect of the adequate stimulus of a nociceptor is like that of pressing an electric button that sets great machinery in motion. From Wordnik.com. [The Origin and Nature of the Emotions: Miscellaneous Papers] Reference
The location of impact on the skin was adjusted slightly between two successive stimuli to avoid nociceptor sensitization and fatigue. From Wordnik.com. [The Neurocritic] Reference
Kanui TI (1987) Thermal inhibition of nociceptor-driven spinal cord neurones in the cat: a possible neuronal basis for thermal analgesia. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
It is the spontaneous activity of the damaged and dysfunctional nerves which convey impulses to the spinal cord nociceptor nerve structures, and thence to the higher centres. From Wordnik.com. [Citizendium, the Citizens' Compendium - Recent changes [en]] Reference
A second physical origin for pain is damage to the nociceptor nerves themselves; this is important because it is very difficult to treat, tends to be long standing, and may not be diagnosed easily. From Wordnik.com. [Citizendium, the Citizens' Compendium - Recent changes [en]] Reference
For example, the impulse from the delicate ticklish points of the skin, whose adequate stimulus is an insect-like contact, could not successfully compete for the final common path with the stimulus of a nociceptor. From Wordnik.com. [The Origin and Nature of the Emotions: Miscellaneous Papers] Reference
Slide 8: Introduction "Radionuclide therapy is useful in nociceptor pain patients but not for neuropathy pain" pain • nociceptor pain: patient as being of a stinging, gnawing or dull character gnawing or dull character. From Wordnik.com. [Recently Uploaded Slideshows] Reference
The central nervous system itself is insensitive to pain (it does not contain nociceptor nerve fibres) and the pain is felt by the sufferer to be located somewhere else in the body, as is the case with peripheral nerve injury. From Wordnik.com. [Citizendium, the Citizens' Compendium - Recent changes [en]] Reference
In the abdominal viscera, as in the superficial parts, nociceptors have presumably been developed by specific harmful influences and each nociceptor is open to stimulation only by a stimulus of the particular type that produced it. From Wordnik.com. [The Origin and Nature of the Emotions: Miscellaneous Papers] Reference
If this be true, then if every nociceptor in the body were equally stimulated in such a manner that all the stimuli should reach the brain-cells simultaneously, then the cells would find themselves in equilibrium and no motor act would be performed. From Wordnik.com. [The Origin and Nature of the Emotions: Miscellaneous Papers] Reference
Spontaneous burning pain, for example, may be driven by ectopic discharges in heat-sensitive nociceptor neurons, whereas pain evoked by brush stroke (dynamic tactile allodynia) is more likely to result from an increase in the excitability of dorsal horn neurons. From Wordnik.com. [PLoS Medicine: New Articles] Reference
There are other definitions of pain, and recent advances in imaging of the brain in pain (e.g. fMRI, SPECT), as well as the identification of biochemical markers of nociceptor nerve activity (e.g. C-fos) may allow more specific descriptions of the phenomenon of pain. From Wordnik.com. [Citizendium, the Citizens' Compendium - Recent changes [en]] Reference
Clinical evidence regarding this point is abundant, for in patients with Graves 'disease we find that the three types of conversion of energy resulting from emotional stimulation, from infection stimulation, and from nociceptor stimulation (pain), are, as nearly as can be judged, equally exaggerated. From Wordnik.com. [The Origin and Nature of the Emotions: Miscellaneous Papers] Reference
@NYC RVT - If the study was titled something a little more snarky like "Enhanced mechanoreceptor stimulation moderates nociceptor output" would you be so skeptical?. From Wordnik.com. [ScienceBlogs Channel : Life Science] Reference
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