For cholesterol to be absorbed in the intestine, however, it would hitchhike with a chylomicron a fat and protein combination or lipoprotein. From Wordnik.com. [Anatomy of a statin ad | The Blog of Michael R. Eades, M.D.] Reference
Each chylomicron contains significant quantities of cholesterol estimated to be 40 times more than that for low-density lipoproteins LDL the so-called "bad" cholesterol. From Wordnik.com. [Australian protein study | The Blog of Michael R. Eades, M.D.] Reference
The group following the low-fat, higher carbohydrate diet has a “substantially exaggerated” response in terms of chylomicron levels after the fat challenge than did those on the higher-protein diet. From Wordnik.com. [Australian protein study | The Blog of Michael R. Eades, M.D.] Reference
LRP1 is a multifunctional endocytic receptor participating in the removal of TG-rich VLDL and chylomicron remnants in the liver. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
The liver removes the chylomicron fragments, and the cholesterol is repackaged for transport in the blood in very low-density lipoproteins (VLDLs), which eventually turn into low-density lipoproteins (LDL). From Wordnik.com. [Recently Uploaded Slideshows] Reference
Patients with abetalipoproteinemia develop severe vitamin E deficiency because they are defective in three steps in this pathway: First, along with other fat soluble vitamins, the fat malabsorption decreases the absorption of vitamin E Second, the small amount of vitamin E that maybe absorbed can not be efficiently secreted by the intestine because of the defect in the chylomicron secretion. From Wordnik.com. [Recently Uploaded Slideshows] Reference
Apo E • Present in 3 isoforms • E2, E3, E4 • Is found in chylomicrons and IDL that binds to a specific receptor on liver cell • It is essential for the normal catabolism of triglyceride-rich lipoprotien constituent • E2 binds poorly to receptors homozygous poor clearance of chylomicron remnants and IDL • E4 associated with increased susceptibility to late onset of Alzheimer's disease 27. From Wordnik.com. [Recently Uploaded Slideshows] Reference
(1998) Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
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