Conversely, despite a significant reduction of cytolysis levels by 23. 22\% and of IR by 21. 4\%, valsartan did not improved liver histology (except steatosis) and had no effect on plasma lipids. From Wordnik.com. [Science Blog - Science news straight from the source] Reference
The Ruhl method involved enzymatic dissociation of myenteric plexus samples, the purification of enteric glial cells via complement-mediated cytolysis of contaminating cells, and transformation by retroviral gene transfer. From Wordnik.com. Reference
They compared the efficacy of telmisartan vs valsartan in a randomized double blind pilot trial assessing insulin resistance, cytolysis and NASH activity score (NAS) in 54 patients with NASH and mild-to moderate hypertension. From Wordnik.com. [Science Blog - Science news straight from the source] Reference
The strong cytotoxic activity of our UCB-derived NK cells against various tumor cell lines as well as the cytolysis of primary AML cells were displayed by specific lysis, CD107a-mediated degranulation and the production of IFNγ. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
The results showed that shRNA inhibition of DAF and MCP expression enhanced complement-dependent cytolysis (CDC) up to 39% for MCP and up to 36% for DAF, and the combined inhibition of both regulators yielded further additive effects in ME180 cells. From Wordnik.com. [BioMed Central - Latest articles] Reference
This is one of the first human blinded trials evaluating the effects of telmisartan and valsartan in steatohepatitis that uses paired liver biopsies with NAS evaluation, simultaneously with cytolysis, insulin resistance, and lipid profile assessment. From Wordnik.com. [Science Blog - Science news straight from the source] Reference
By observing in clinical conditions significant reduction of insulin resistance by both ARBs, as well as a moderate decrease of cytolysis, the study confirms that ARBs not only can correct hypertension, but also can act by preventing and treating steatohepatitis as an end-organ effect of metabolic syndrome. From Wordnik.com. [Science Blog - Science news straight from the source] Reference
The group followed-up the patients for 20 months observing that although serum aminotransferases did not normalize in either group, telmisartan reduced cytolysis by 30. 28\% and improved insulin resistance by 42. 63\% consequently with a significant decrease of NAS and fibrosis scores and an amelioration of the lipid profile. From Wordnik.com. [Medlogs - Recent stories] Reference
The group followed-up the patients for 20 months observing that although serum aminotransferases did not normalized in either group, telmisartan reduced cytolysis by 30. 28\% and improved insulin resistance by 42. 63\% consequently with a significant decrease of NAS and fibrosis scores and an amelioration of the lipid profile. From Wordnik.com. [Science Blog - Science news straight from the source] Reference
The primary endpoints of the study were to prove that ARBs can ameliorate insulin resistance in mild-to-moderate hypertensive patients with histologically confirmed NASH, showing that monotherapy with ARBs on a regularly base can ameliorate cytolysis and NAS, while the secondary endpoint was to prove certain superiority of telmisartan vs valsartan probably linked to its specific insulin sensitizing action releated to the peroxisome proliferator activated receptor (PPAR) gamma - modulatory effects. From Wordnik.com. [Science Blog - Science news straight from the source] Reference
(2008) Inhibition of anthrax lethal toxin-induced cytolysis of RAW264. 7 cells by celastrol. From Wordnik.com. [PLoS Biology: New Articles] Reference
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