Extensive search through the model parameter space produced only long-term scrapie persistence for ε3 ≥ 0.01.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The steady state prevalence is however the same for different values of β1 corresponding to long-term scrapie persistence (.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

"I didn't drive it particularly well, so I was a little 'scrapie' on the front nine," he said.    From Wordnik.com.  [Columnist: Keith Groller] Reference

These transgenic mice came down with a scrapie-like disease.    From Wordnik.com.  [Physiology or Medicine for 1997 - Press Release] Reference

Frank Pulley -- it has all the appearance of being scrapie-related.    From Wordnik.com.  [On Thursday, the Legg report will be published along with...] Reference

The mystery behind scrapie, kuru, and mad cow disease has finally been unravelled.    From Wordnik.com.  [The Nobel Prize in Physiology or Medicine 1997 - Presentation Speech] Reference

Kingsbury on linking the PrP gene to the control of scrapie incubation time in mice.    From Wordnik.com.  [Stanley B. Prusiner - Autobiography] Reference

On Iceland, scrapie, a disease affecting sheep was first described in the 18th century.    From Wordnik.com.  [The Nobel Prize in Physiology or Medicine 1997 - Presentation Speech] Reference

It also banned scrapie-infected sheep, which may have saved America from mad-cow disease.    From Wordnik.com.  [The Battle Over Caution] Reference

With her husband Max she had irradiated the scrapie virus, which became important in the 1990s.    From Wordnik.com.  [Tikvah Alper.] Reference

Virologists were generally incredulous and some investigators working on scrapie and CJD were irate.    From Wordnik.com.  [Stanley B. Prusiner - Autobiography] Reference

Simply dont eat this meat then , Thats how mad cow BSE disease came about, also how sheep get scrapie.    From Wordnik.com.  [Think Progress » Gerald Ford opposed the Iraq war.] Reference

The tedious, slow, and very expensive assays in mice for the scrapie agent had restricted progress and.    From Wordnik.com.  [Stanley B. Prusiner - Autobiography] Reference

(Though on reflection it might be a Scottish cut, as in "He fell down and got a wee scrapie on his knee.").    From Wordnik.com.  [I'm A Stranger Here Myself]

PrPc can undergo a conformational change, adopting a harmful, disease-causing shape termed PrP-scrapie, or.    From Wordnik.com.  [Physiology or Medicine for 1997-Animation] Reference

Ruth Gabizon dispersed prions into liposomes and purified scrapie infectivity on columns with PrP antibodies.    From Wordnik.com.  [Stanley B. Prusiner - Autobiography] Reference

In England BSE was transmitted to cows through feedstuff supplemented with offals from scrapie-infected sheep.    From Wordnik.com.  [Physiology or Medicine for 1997 - Press Release] Reference

Two related diseases, scrapie in sheep and chronic wasting disease in deer, elk and moose, spread much more easily.    From Wordnik.com.  [Archive 2008-09-01] Reference

In addition, there have never been any indications of human illness related to scrapie, a prion disease found in sheep.    From Wordnik.com.  [New Jersey Approves Crossbows For Archery Deer] Reference

Eventually, I managed to gain modest NIH support for my scrapie studies but this was not without considerable difficulty.    From Wordnik.com.  [Stanley B. Prusiner - Autobiography] Reference

I did think that after working with the scrapie agent for some time that I might eventually be able to develop such an assay.    From Wordnik.com.  [Stanley B. Prusiner - Autobiography] Reference

The prion that causes scrapie has been found in low density in sheep muscle tissue (meat), not just in the brain and spinal cord.    From Wordnik.com.  [grouse Diary Entry] Reference

They taught me an immense amount about scrapie and helped me initiate studies on the sedimentation behavior of the scrapie agent.    From Wordnik.com.  [Stanley B. Prusiner - Autobiography] Reference

There was a lot of concern that this may have spread to sheep, but had not been detected because of a similar disease called scrapie.    From Wordnik.com.  [Lost Cedars #2 « Climate Audit] Reference

My initial intention was to work on sheep scrapie, but I quickly realised that this was not a good project area for an experimentalist.    From Wordnik.com.  [Peter C. Doherty - Autobiography] Reference

Then they exposed them to a prion disease known as scrapie.    From Wordnik.com.  [Medlogs - Recent stories] Reference

In particular, it may have consequences on the long-term persistence of scrapie.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In contrast, higher β1 requires a lower p0 for preventing scrapie to disappear.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

When β1 is low (i.e. 2. 0), scrapie persists only when p0 is relatively high (~84. 5%).    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The range of model parameters leading to persistence of scrapie is narrow, but realistic.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Figure 2 for p0 = 0.54 and ε3 = 0.05, scrapie is only predicted to persist when 4.80 ≤ β1 ≤ 4.93.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Sheep are characterised by their scrapie infection status (infected or not infected), age and PrP genotype.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

N = 100,000 and therefore the prevalence threshold below which scrapie was considered eradicated was 0. 001%.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The PrP genotype was assumed to be only associated with scrapie susceptibility and post-natal lamb mortality in our model.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

There are several reasons that explain why the range of model parameters leading to long-term persistence of scrapie is narrow.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Lambs with scrapie resistant genotypes were found to have significantly lower survival rates than those with susceptible genotypes.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Additionally, it showed higher CDK5, but lower GSK3 beta transcriptional and expressive levels in the brains of scrapie-infected animals.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

This information will help establish a time frame in which scrapie can be eradicated from Canada and international markets can be reopened.    From Wordnik.com.  [NewsBlaze.com Current News - Top Stories] Reference