Activation of keratinocyte intracellular signaling pathways is emerging as an important component of pemphigus IgG-mediated acantholysis.    From Wordnik.com.  [Journal of Biological Chemistry current issue] Reference

The skin showed hyperplasia and acantholysis in the mid - and lower epidermal layers, whereas the heart showed extensive fibrosis and fibrofatty replacement in both ventricles.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

Furthermore, these observations suggest that the earlier peak of p38MAPK activation is part of the mechanism leading to acantholysis, whereas the later peak of p38MAPK and apoptosis may not be essential for acantholysis.    From Wordnik.com.  [Journal of Biological Chemistry current issue] Reference