S-acylation that take place on conserved C-terminal cysteine residues.    From Wordnik.com.  [PLoS Biology: New Articles] Reference

(C) ERAT is specific for Ser5: lack of acylation of the GAM-proghrelin mutants and preproghrelin.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

S-acylation and consequent partitioning into detergent resistant membranes that could be lipid rafts.    From Wordnik.com.  [PLoS Biology: New Articles] Reference

In order to investigate this idea, we asked whether zinc activation precedes the acylation step or coincides with it.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

We identify APT1 as one of the thioesterases in the acylation cycle and show that this protein is a cellular target of the inhibitor.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

Based on these data, we conclude that the acylation of acylglycerols by DGAT1 is important for dietary fat absorption in the intestine.    From Wordnik.com.  [Journal of Biological Chemistry current issue] Reference

Mutagenesis studies indicated a requirement for serine five residues from the amino terminus, reminiscent of myristoyl transferase, but not of ghrelin acylation.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Interference with acylation using small molecules is a strategy to modulate cellular localization-and thereby unregulated signaling-caused by palmitoylated Ras proteins.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

The inhibitor, palmostatin B, perturbs the cellular acylation cycle at the level of depalmitoylation and thereby causes a loss of the precise steady-state localization of palmitoylated Ras.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

Protein acylation is increasingly recognized as critical for the regulation of a wide variety of cellular processes, including gene expression, protein localization, and intracellular signaling.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

These two results support the idea that ERAT represents a single catalytic entity, although the tight association of a metal-stimulated protease which acts in conjunction with acylation cannot definitively be ruled out.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

This could consist either of zinc-dependent proteolytic activation of ERAT, or a zinc-dependent proteolytic processing of the substrate (for example, to expose a putative acylation consensus sequence, similar to that seen for myristoylation).    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In order to determine whether zinc acts during acylation or at an earlier step, aliquots of the active fraction from Mini-S chromatography were preincubated with GAM-proghrelin at 37C for 30 min in the presence of either 5 mM EDTA or 0.1 mM ZnCl.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Department of Anatomy and Neurobiology, University of Maryland-Baltimore, Baltimore, Maryland, United States of America Non-histone protein acylation is increasingly recognized as an important posttranslational modification, but little is known as to the biochemical properties of protein serine acylating enzymes.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Last night I was even at the stage of sitting in the exam hall waiting to be told to open the test paper, when I realised that I could recall not one of the countless details of reagents, methods and strategies involved in the Grignard reaction in particular (yes, alkylmagnesium, I know that much) or the aldol reaction, Claesen rerrangement, Friedel-Crafts acylation and all the rest.    From Wordnik.com.  [homunculus] Reference

However, EDTA addition was still able to dramatically reduce acylation in a zinc-preincubated reaction (.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

We have also found that XP620 is an inhibitor that selectively inhibits the acylation of MAG by DGAT1 (IC50 of human DGAT1: 16.6 ± 4.0 n.    From Wordnik.com.  [Journal of Biological Chemistry current issue] Reference

2 and / or EDTA were added to the preincubated reactions in order to adjust the final concentrations during acylation, as shown in ERAT purification using Mini-S chromatography and gel filtration.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

(2006) The acylation state of mycobacterial lipomannans modulates innate immunity response through toll-like receptor 2.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Ibuprofen friedel-crafts acylation.    From Wordnik.com.  [quotes « WordPress.com Tag Feed] Reference

), the major acylation product by DGAT1 was TAG; however, increased concentrations of 2-MAG (50-200 µM) resulted in decreased TAG formation.    From Wordnik.com.  [Journal of Biological Chemistry current issue] Reference