It has been proposed that the open chain aldose while on the enzyme undergoes torsional inversion at the C2-C3 bond before ring closing.    From Wordnik.com.  [Irwin Rose - Autobiography] Reference

They also reported that activity of the enzyme, known as aldose reductase, can be significantly reduced by compounds that have already undergone clinical trials as treatments for complications of diabetes.    From Wordnik.com.  [The Daily News - News] Reference

NFAT5 regulates the adaptation of mammalian cells to hypertonic stress by inducing the expression of osmoprotective gene products that include chaperones and a number of enzymes and transporters, such as aldose reductase (AR), whose collective function is to increase the intracellular concentration of compatible organic osmolytes that allow cells to adapt and survive in a hypertonic environment.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Thus a-xylose were the substrates for the 2R-aldose enzymes in their production of fructose.    From Wordnik.com.  [Irwin Rose - Autobiography] Reference

I had been looking for evidence of proton transfer in enzymes that catalyzed aldose-ketose interconversions.    From Wordnik.com.  [Irwin Rose - Autobiography] Reference

If now the aldose groups tend to pass over into the starch form, representing a temporary overflow product of the assimilating energy, it would appear that the ketose or levulose groups are preferentially used up in the elaboration of the permanent tissue.    From Wordnik.com.  [Researches on Cellulose 1895-1900] Reference

The reason it is a 4 membered ring is because it is a ketose, as opposed to an aldose.    From Wordnik.com.  [ScienceBlogs Channel : Life Science] Reference

All four compounds also inhibit aldose reductase, a target enzyme for pharmacological control of diabetic complications.    From Wordnik.com.  [Wil's Ebay E-Store] Reference

Moriyama T, Garcia-Perez A, Burg MB (1989) Osmotic regulation of aldose reductase protein synthesis in renal medullary cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Dihydroflavonol taxifolin and its glycoside, astilbin, from Engelhardtia chrysolepis inhibited rat lens and recombinant human aldose reductase.    From Wordnik.com.  [Wil's Ebay E-Store] Reference

NCV, QST and NIS-LL have all been used as primary or secondary endpoint in large pivotal trials of aldose reductase inhibitors and nerve growth factors in diabetic neuropathy.    From Wordnik.com.  [Biotech Sector and Stocks Analysis from Seeking Alpha] Reference

Biosci Biotechnol Biochem 1997 Apr; 61 (4): 651-654 Inhibition of aldose reductase and sorbitol accumulation by astilbin and taxifolin dihydroflavonols in Engelhardtia chrysolepis.    From Wordnik.com.  [Wil's Ebay E-Store] Reference

Lee AY, Chung SK, Chung SS (1995) Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Moreover, inhibition of the enzyme aldose reductase (ALR2), which converts glucose to sorbitol, was also observed when red blood cells were incubated with the hot water extract and some of the components.    From Wordnik.com.  [NutraIngredients-USA RSS] Reference

I am a in sharp rein but i get revolting when meryta aldose that ultimateness enets is clew religiously the blowhard, or that all jacobinical remuneration are retral, or that antilles demographer is aerobic.    From Wordnik.com.  [Rational Review] Reference

(an inhibitor of aldose reductase enzyme) and letrozole (an aromatase inhibitor) could delay or stop tumor resistance to endocrine therapy, according to data presented at the CTRC-AACR San Antonio Breast Cancer Symposium.    From Wordnik.com.  [Newswise: Latest News] Reference

So we thought, why not find out if aldose reductase inhibition also has an effect on asthma? ".    From Wordnik.com.  [dailyindia.com News Feed] Reference

In the same experiments, NFAT5-deficient lymphocytes displayed a defective osmoprotective response, with poor induction of Hsp70. 1, aldose reductase, SMIT, and SNAT2 (.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

5′-ACC TGG TCC TAT GAG AAT CTA ACG-3′ (Reverse); mouse aldose reductase (AR).    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

(1988) Osmoregulation by slow changes in aldose reductase and rapid changes in sorbitol flux.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

6P+NH3 and xylulose, respectively, and b-L-arabinose and B-D-mannose-6-P were the specific substrate for the 2S-aldose isomerase.    From Wordnik.com.  [Irwin Rose - Autobiography] Reference