The most successful compound to emerge from this approach was the 1-methyl-4-nitro-5 imidazolyl derivative, the compound now known as azathioprine (Imuran®).    From Wordnik.com.  [Nobel Lecture The Purine Path To Chemotherapy] Reference

Other studies have demonstrated that azathioprine, which is in the thiopurine class, can increase the photosensitization of human skin. ".    From Wordnik.com.  [PhysOrg.com - latest science and technology news stories] Reference

Meanwhile, the pursuit of 6-MP, thioguanine, azathioprine and allopurinol had occupied 20 years.    From Wordnik.com.  [Nobel Lecture The Purine Path To Chemotherapy] Reference

Later he could show that a still better effect was obtained with the cytotoxic drug azathioprine.    From Wordnik.com.  [Physiology or Medicine 1990 - Press Release] Reference

For a long time azathioprine was the only drug available to prevent rejection of transplanted organs.    From Wordnik.com.  [Physiology or Medicine 1988 - Press Release] Reference

The result was azathioprine (1957) which replaced mercaptopurine as an inhibitor of the immune response.    From Wordnik.com.  [Physiology or Medicine 1988 - Press Release] Reference

In patients with leukemia, however, the chemotherapeutic index of 6-MP and azathioprine were similar (51).    From Wordnik.com.  [Nobel Lecture The Purine Path To Chemotherapy] Reference

The immunosuppressive effects of azathioprine have been studied in a wide variety of immunological systems.    From Wordnik.com.  [Nobel Lecture The Purine Path To Chemotherapy] Reference

Efficacy of intravenous loading of azathioprine in children and adolescents with inflammatory bowel disease.    From Wordnik.com.  [Clinical studies: IBD treatment approaches] Reference

Experiences with 6-mercaptopurine and azathioprine therapy in pediatric patients with severe ulcerative colitis.    From Wordnik.com.  [IBD clinical studies: drug comparisons] Reference

The patients 'average age at the initiation of treatment with 6-mercaptopurine and azathioprine was 13.8 years.    From Wordnik.com.  [IBD clinical studies: drug comparisons] Reference

In particular, the glutathione present in red cells reacts with azathioprine, releasing 6-MP back into the plasma (47).    From Wordnik.com.  [Nobel Lecture The Purine Path To Chemotherapy] Reference

The first renal transplant recipient to receive azathioprine was an adult transplanted with an unrelated kidney in March 1961.    From Wordnik.com.  [Joseph E. Murray - Nobel Lecture] Reference

Increased dosing requirements for 6-mercaptopurine and azathioprine in inflammatory bowel disease patients six years and younger.    From Wordnik.com.  [Recent Publications] Reference

The median time to discontinuation of corticosteroid after initiation of 6-mercaptopurine and azathioprine therapy was 8.4 months.    From Wordnik.com.  [IBD clinical studies: drug comparisons] Reference

The studies which followed showed azathioprine to be superior to 6-MP for preventing rejection of canine kidney homografts (58,59).    From Wordnik.com.  [Nobel Lecture The Purine Path To Chemotherapy] Reference

When Calne asked us for compounds related to 6-MP which he might investigate, we suggested that azathioprine might have some advantages.    From Wordnik.com.  [Nobel Lecture The Purine Path To Chemotherapy] Reference

Elion participated in much of the subsequent work with the compound and the agents that followed, including azathioprine and allopurinol.    From Wordnik.com.  [George H. Hitchings - Autobiography] Reference

Successful transplantation of kidneys to unrelated recipients became a reality in man in 1962, with regimens of immunosupression consisting of azathioprine and prednisone (60).    From Wordnik.com.  [Nobel Lecture The Purine Path To Chemotherapy] Reference

Two patients on azathioprine developed colon cancer.    From Wordnik.com.  [Medicaid and Medicare] Reference

Crohn's disease than azathioprine alone, researchers report.    From Wordnik.com.  [Medlogs - Recent stories] Reference

"You take azathioprine?" she asked, looking up from her clipboard.    From Wordnik.com.  [NYT > Home Page] Reference

The trial showed that the azathioprine-alone step should be skipped.    From Wordnik.com.  [Medlogs - Recent stories] Reference

Evaluation of topical cromolyn sodium in the azathioprine in Behcet's syndrome.    From Wordnik.com.  [Recently Uploaded Slideshows] Reference

Results of study comparing REMICADE to azathioprine for Crohn's disease published.    From Wordnik.com.  [THE MEDICAL NEWS] Reference

Another treatment, azathioprine, is taken orally, and suppresses the immune system.    From Wordnik.com.  [Medlogs - Recent stories] Reference

These suppress the production of abnormal antibodies and include steroids and azathioprine.    From Wordnik.com. Reference

Nonetheless, outcomes generally were better with azathioprine, with significantly fewer deaths.    From Wordnik.com.  [MedPageToday.com - medical news plus CME for physicians] Reference

These patients also took other immunosuppressive agents, such as methotrexate and azathioprine.    From Wordnik.com.  [WN.com - Articles related to Freedom to set prices key for UK drugs industry] Reference

Sometimes tacrolimus is given instead of cyclosporine and mycophenolate mofetil instead of azathioprine.    From Wordnik.com.  [Find Me A Cure] Reference

One-third were given infliximab alone, one-third received only azathioprine and one-third were treated with both.    From Wordnik.com.  [Medlogs - Recent stories] Reference

The results were reported in the April 15 issue of the azathioprine, which reduces immune system activity broadly.    From Wordnik.com.  [Medlogs - Recent stories] Reference

Both the infliximab combination therapy and infliximab monotherapy groups were statistically superior to the azathioprine group.    From Wordnik.com.  [Medlogs - Recent stories] Reference

Therapy with both azathioprine and infliximab appears to be the treatment of choice if steroids are not effective, Sandborn said.    From Wordnik.com.  [Medlogs - Recent stories] Reference

Of the 20 patients randomized to receive oral azathioprine, 14 achieved remission, although eight relapsed within a mean of 25 months.    From Wordnik.com.  [MedPageToday.com - medical news plus CME for physicians] Reference

More relapses were seen in the azathioprine group, which led investigators to suggest that a six-month course of the drug was inadequate.    From Wordnik.com.  [MedPageToday.com - medical news plus CME for physicians] Reference

Half of these had another course of azathioprine and others were given cyclophosphamide or high-dose steroids and again reached remission.    From Wordnik.com.  [MedPageToday.com - medical news plus CME for physicians] Reference

They found that infliximab alone or in combination with azathioprine was a statistically more effective treatment than azathioprine alone.    From Wordnik.com.  [Medlogs - Recent stories] Reference