In the new study, Xue and his team found that a well-known cellular molecule called caspase.    From Wordnik.com.  [PhysOrg.com - latest science and technology news stories] Reference

This protein, known as caspase 8, is deficient in humans with eczema, but produced in excess amounts by diabetics.    From Wordnik.com.  [EurekAlert! - Breaking News] Reference

For example, it activates the enzyme caspase, which is involved in processes that lead to apoptosis (programmed cell death).    From Wordnik.com.  [innovations-report] Reference

In turn, caspase-8 recruits the mitochondrial pathway for apoptosis and activates executioner caspases, such as caspase-3, that are responsible for cell death.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The caspase 3s will go about cleaving other cytoplasmic proteins.    From Wordnik.com.  [2008 March - Telic Thoughts] Reference

Rapa inhibits caspase activation in cdc13-1 cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

FLICA caspase inhibitor and analysed by fluorescence microscopy.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

Immunofluorescent labeling for active caspase 3 and TUNEL assay.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The pan-caspase inhibitor Q-VD-OPH was used at a concentration of 5 µM.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Activity in this assay is inhibited by the pan-caspase inhibitor zVAD-fmk.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9.    From Wordnik.com.  [WN.com - Articles related to DTI favors zero tariffs on cement, wheat] Reference

Additionally, the on-treatment measure of cytokeratin-18 caspase cleavage fragments.    From Wordnik.com.  [PhysOrg.com - latest science and technology news stories] Reference

Western blot analysis showed that 22.2 mmol / l glucose did not affect caspase 3 cleavage.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

To determine if PMN caspase activation occurs similar to macrophages following interaction with.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Our caspase inhibitor 9450 continues to make progress as hepatoprotectant both in HCV and NASH.    From Wordnik.com.  [SeekingAlpha.com: Home Page] Reference

Cell death induced by SC/D-F9 occurred via apoptosis with the involvement of caspase 3 and/or 7.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

A primary function of the inflammatory caspase family is the regulation of the inflammatory response.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Induction of caspase activity is YopJ/YopP dependent but delayed in human MDMs compared to J774A. 1 cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

For the in vitro caspase 3/7 assay, lysates were combined with a lumogenic substrate containing the DEVD sequence.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The apoptosome cleaves the pro-caspase to its active form of caspase-9, which in turn activates the effector caspase-3.    From Wordnik.com.  [WN.com - Articles related to DTI favors zero tariffs on cement, wheat] Reference

Yersinia did not result in PMN caspase activation, release of LDH, or loss of membrane integrity greater than PMN controls.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Other panels show nuclear stain (center) and immunofluorescence (right) against cleaved caspase 3, an indicator of apoptosis.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

We further observed that both the caspase and calpain inhibitors reduced the activation of caspases with an equal efficiency.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Unlike caspase activation observed in macrophages, neither caspase-3, -8, -9, nor -2 activity increased in PMNs incubated with.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The role of two cysteine proteases; caspase and calpain has been highly implicated in programmed cell death in many cell systems.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

(A) Combined caspase 3 and 7 activities in K562 cells treated with 5 nM PSI, 10 µM salubrinal and 2 mM VPA as indicated for 18 h.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in.    From Wordnik.com.  [WN.com - Articles related to DTI favors zero tariffs on cement, wheat] Reference

Vissers MC, Dragunow M, Hampton MB (2007) A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

This approach lead to the identification of 20 agents that induced strong increases in the levels of caspase-cleaved cytokeratin 18 in colon carcinoma cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

But when caspase comes in contact with Dicer, it takes away Dicer's ability to cleave RNA and it replaces it with the ability to snip up and destroy DNA-laden chromosomes.    From Wordnik.com.  [PhysOrg.com - latest science and technology news stories] Reference

These aberrations often reside in signalling proteins that control the activation of the apoptotic machinery or in the Bcl-2 family of proteins that control caspase activation.    From Wordnik.com.  [Naturejobs - All Jobs] Reference