We also show that case-control comparisons of affected post mortem brain tissue are more likely to reflect terminal cytoarchitectural differences rather than primary pathogenic mechanisms.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Microarray data of predilection sites such as the SN illustrates cytoarchitectural differences between cases and controls but to understand some of the early pathogenic processes, we would ideally want to assay a brain region very similar to SN but that is only belatedly affected.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference