The agents of this complex enterprise of surveillance are, once again, the lymphocytes -- specifically, cytolytic T lymphocytes.    From Wordnik.com.  [Vaccinating Against Cancer] Reference

Knuth turned his attention to the relationship between a subset of immune cells known as cytolytic ( "cell-killing") T lymphocytes and Frau H. 's melanoma cells.    From Wordnik.com.  [Vaccinating Against Cancer] Reference

Again, cytolytic T cells are incapable of detecting an antigen -- be it a snippet of flu virus or a scrap of MAGE-1 -- unless it is presented on the surface of the cell by MHC molecules.    From Wordnik.com.  [Vaccinating Against Cancer] Reference

The German researchers peering into their lab dishes saw, to their surprise, that a small number of Frau H. 's cytolytic T lymphocytes not only recognized the melanoma cells from her body but killed them in the test tube.    From Wordnik.com.  [Vaccinating Against Cancer] Reference

Bacillus thuringiensis subsp. israelensis cytolytic toxins.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Cytokine responses and cytolytic activity in target organs.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

T-cell cytolytic activity may be effective in clearing HBV infection.    From Wordnik.com.  [THE MEDICAL NEWS] Reference

Inflammatory and cytolytic effects of PLN on mouse alveolar macrophage MH-S cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Drug-induced hepatitis (eg, acute hepatitis, cytolytic hepatitis) has been reported with PREZISTA/r.    From Wordnik.com.  [The Earth Times Online Newspaper] Reference

The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease.    From Wordnik.com. Reference

TITLE: The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease.    From Wordnik.com.  [Health News from Medical News Today] Reference

The granzyme family members are serine proteases that are present in the secretory granules of cytolytic T lymphocytes.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

Our data suggests that this approach can enhance the overall number of RCC-specific cytolytic T lymphocytes in the peripheral blood.    From Wordnik.com.  [Health News from Medical News Today] Reference

In contrast, KG1a cells hardly stimulated degranulation of these NK cell products, indicating that cytolytic activity is inhibited by HLA expression.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Human cell exposure assays of Bacillus thuringiensis commercial insecticides: production of Bacillus cereus-like cytolytic effects from outgrowth of spores.    From Wordnik.com.  [Organic Consumers Association News Headlines] Reference

The nature of the enhanced antitumor immune response seems to be mediated through the enhanced cytolytic activity of cytotoxic T lymphocytes (CTLs) and IFN.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

This specificity is especially interesting considering the novel function recently demonstrated for dNK as cytokine secretors rather than strictly cytolytic executors.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The trial is being initiated by our collaborators at the City of Hope and is designed to evaluate the safety and tolerability of a modified CD9-positive cytolytic T lymphocyte or CTL product.    From Wordnik.com.  [Biotech Sector and Stocks Analysis from Seeking Alpha] Reference

Mitchison NA, O'Malley C (1987) Three-cell-type clusters of T cells with antigen-presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

IL-2 (0 h) effector cells is caused by greater cytolytic function of the cells transferred, we checked the production of granzyme B and IFNγ of the tumor-infiltrating lymphocytes of effector cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The study showed an interesting association of HBsAg loss in HIV-HBV co-infected patients with higher CD4 cell count, suggesting that T-cell cytolytic activity against HBV may still be effective in clearing HBV infection.    From Wordnik.com.  [THE MEDICAL NEWS] Reference

In contrast, the remaining 90% of the NK cells, the CD56 dim cytotoxic NK cell subset, produces relatively lower cytokine levels, but possesses an abundance of cytolytic granules and can spontaneously lyse susceptible target cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In the 1980's, it was discovered that tumor cells can be recognized by cytolytic T lymphocytes (CTL), an important component of the immune system, which recognizes antigens on tumor cells and kills them without harming normal tissues.    From Wordnik.com.  [The Earth Times Online Newspaper] Reference

Genetic variations may also affect the immune response, because small variations in the ability of an individual to mount an effective cytolytic defence, together with the tumour cell's ability to downregulate specific antigens, might be important in the metastatic cascade.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

New and emerging areas such as molecular imaging in evaluating the response and resistance to targeted radiotherapy, a discussion of the bystander effect which may enhance its effectiveness, and the potential of combining cytolytic virus therapy with targeted radiotherapy have also been included.    From Wordnik.com.  [Business Wire Travel News] Reference

+-depleted PBSC grafts leads to early NK cell repopulation and reconstitution of the CD56 dim and CD56bright NK cell subsets, with concomitant high cytolytic capacity.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

+-depleted grafts facilitates strong NK cell cytolytic responses directly after SCT, and the rapid emergence of an NK cell receptor phenotype that is more prone to activation.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

To determine cytolytic activity of these subsets and investigate if this activity is regulated by the expressed inhibitory receptors, we performed CD107a-based degranulation assays using HLA-negative K562 cells and KG1a cells expressing relatively high levels of HLA-ABC and - E (see.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference