The normal expression of human beta globin is highly dependent upon the stability of its encoding mRNA. From Wordnik.com. [Sickle cell disease research at The Children's Hospital] Reference
If no or badly functioning beta-globin is made, the life-span of the red blood cells is shortened resulting in anemia. From Wordnik.com. [Physiology or Medicine 1993 - Press Release] Reference
A faulty beta-globin protein is made, leading to severe anemia. From Wordnik.com. [Poster-Medicine-1993] Reference
The globin family story is a good example of this type of approach. From Wordnik.com. [Flagellum evo -- further discussion - The Panda's Thumb] Reference
Novel approaches to increase gamma-globin expression in sickle cell disease. From Wordnik.com. [Sickle cell disease research at The Children's Hospital] Reference
In the upper part of figure 3 the normal splicing of beta-globin RNA is shown (A). From Wordnik.com. [Physiology or Medicine 1993 - Press Release] Reference
What I had in mind was something like what Morris Goodman did for the globin gene story. From Wordnik.com. [Update on PNAS flagellum paper - The Panda's Thumb] Reference
Rejection of the ‘flying primate’ hypothesis by phylogenetic evidence from the globin gene. From Wordnik.com. [We flightless primates] Reference
Yet breaking pyruvate kinase or G6PD or globin genes in thalassemia does not add up to any new system. From Wordnik.com. [Scientists' Responses Solicited] Reference
Arrows mark two examples of sites where point mutations causing thalassemia occur in the beta-globin gene. From Wordnik.com. [Poster-Medicine-1993] Reference
Isolation and nucleotide sequence analysis of the beta-type globin pseudogene from human, gorilla and chimpanzee. From Wordnik.com. [Behe, Common Descent, & UD] Reference
Kucherlapati, R.S. Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. From Wordnik.com. [The 2007 Nobel Prize in Physiology or Medicine - Advanced Information] Reference
Human fetal Gg and Ag globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes. From Wordnik.com. [The 2007 Nobel Prize in Physiology or Medicine - Advanced Information] Reference
Normal red blood cells contain correctly spliced beta-globin, an important component in hemoglobin that takes up oxygen in the lungs. From Wordnik.com. [Poster-Medicine-1993] Reference
One question: do the resulting cells have enough globin to carry oxygen?. From Wordnik.com. [Science Fiction in the News] Reference
And they have a different form of the globin molecule, which carries oxygen. From Wordnik.com. [Latest Articles] Reference
Second, with overlapping peptides spanning α and β globin and proteolysis-dependent. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Most commonly, mutations occur in the promoter regions preceding the beta-globin genes. From Wordnik.com. [Citizendium, the Citizens' Compendium - Recent changes [en]] Reference
On the other hand, the globin protein parts are incorporated with ribosomes in the cytosol. From Wordnik.com. [CreationWiki - Recent changes [en]] Reference
His first problem was to figure out which of several globin genes were active in the species. From Wordnik.com. [The Seattle Times] Reference
Any given individual has two β globin alleles, one from their mother and one from their father. From Wordnik.com. [Citizendium, the Citizens' Compendium - Recent changes [en]] Reference
The Medical Biochemistry Page Hemoglobin synthesis requires the collaboration of heme and globin. From Wordnik.com. [CreationWiki - Recent changes [en]] Reference
(Normal hemoglobin consists of four globin protein chains - two alpha chains and two beta chains.). From Wordnik.com. [PhysOrg.com - latest science and technology news stories] Reference
The presented data indicate that GLB-1 and GLB-26 belong to two functionally-different globin classes. From Wordnik.com. [BioMed Central - Latest articles] Reference
Thalassemia is classified as alpha or beta thalassemia, depending on which of the globin protein chains are affected. From Wordnik.com. [PhysOrg.com - latest science and technology news stories] Reference
The genome of the nematode Caenorhabditis elegans contains more than 30 putative globin genes that all are transcribed. From Wordnik.com. [BioMed Central - Latest articles] Reference
Fewer globin chains mean a shortage of red blood cells, a shorter lifespan for red cells that are produced, and anemia. From Wordnik.com. [PhysOrg.com - latest science and technology news stories] Reference
There are four genetic loci for α globin, two of which are maternal in origin and two of which are paternal in origin. From Wordnik.com. [Citizendium, the Citizens' Compendium - Recent changes [en]] Reference
This immature hemoglobin, which usually disappears after birth, does not contain beta-globin, but another form called gamma-globin. From Wordnik.com. Reference
This globin oxidizes instantly to the ferric form in the presence of oxygen and is therefore incapable of reversible oxygen binding. From Wordnik.com. [BioMed Central - Latest articles] Reference
He and his colleagues developed a technique to insert the gene for gamma-globin into blood-forming cells using a harmless viral carrier. From Wordnik.com. Reference
Bouloy M, Krug RM (1979) Transfer of 5′-terminal cap of globin mRNA to influenza viral complementary RNA during transcription in vitro. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
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