The scientists propose that several centuries ago, a histiocyte cell in a dog or a wolf turned cancerous.    From Wordnik.com.  [You *can* teach an old dog new tricks - The Panda's Thumb] Reference

These models are limited by their xenogeneic nature, whereas the DR4 mice described here provide cases of spontaneous disease with morphological and phenotypic similarities to human T cell/histiocyte rich DLBCL and HL with characteristic H/RS-like cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

(LTCL), lymphoblastic B cell lymphoma (LBCL), diffuse large B cell lymphoma (DLBCL), the histiocyte/T cell rich variant of DLBCL (DLBCL-HA/T cell rich DLBCL), splenic marginal zone lymphoma (SMZL), follicular B cell lymphoma (FBL) and plasmacytoma (PCT).    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Half of the DLBCL belonged to the morphological histiocyte-associated variant DLBCL-HA (.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference