In addition to muscle weakness, many children have spasticity or hypertonicity in the muscles of the weaker side.    From Wordnik.com.  [Hand Splinting] Reference

Acute effects hypertonicity potential difference rumen wall sheep.    From Wordnik.com.  [xml's Blinklist.com] Reference

Reminder: All hypertonicity is not spasticity and treatment is different.    From Wordnik.com.  [Recently Uploaded Slideshows] Reference

Na KY, Park WK, Kwon HM (2002) TonEBP / NFAT5 stimulates transcription of HSP70 in response to hypertonicity.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Effect of hypertonicity on cyclin induction by mitogens or T cell receptor activation in NFAT5 − / − T cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Altogether, these results indicated that hypertonicity triggered a rapid cell cycle arrest in both wild-type and NFAT5.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Sheen MR, Na KY, Kwon HM (2003) Multiple domains of TonEBP cooperate to stimulate transcription in response to hypertonicity.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Effect of pathologic hypertonicity on the induction of cyclins and aurora B kinase in response to T cell receptor stimulation in NFAT5.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Microarray profiling of wild type worms exposed to non-lethal hypertonicity identified a suite of genes that were also regulated by infection.    From Wordnik.com.  [Elites TV] Reference

Fig. 2A, both NFAT5+ / + and NFAT5 − / − cells displayed a comparable activation of p53 early after exposure to hypertonicity (4-6 hours).    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Nuclear translocation of NFAT5 in response to hypertonicity is mediated by a nuclear localization sequence (NLS) common to the three NFAT5 isoforms.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In response to hypertonicity, NFAT5 translocates to the nucleus, binds to regulatory regions of osmoprotective genes and activates their transcription.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The carboxy-terminal domain, which is acidic and glutamine-rich, spans more than 900 amino acids and is responsible for its hypertonicity-induced transcriptional activity.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

We show that hypertonicity triggered an early, NFAT5-independent, genotoxic stress-like response with induction of p53, p21 and GADD45, downregulation of cyclins, and cell cycle arrest.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

We were interested in analyzing how the deficiency of NFAT5 in proliferating cells affected hypertonicity-regulated processes such as the induction of genotoxic stress-like responses and the cell cycle.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

This interpretation is consistent with the finding that cells lacking the chaperones Hsp70 and Hspa4l / Osp94, whose induction by hypertonicity is NFAT5-dependent, have defects similar to those of NFAT5.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Maallem S, Mutin M, Kwon HM, Tappaz ML (2006) Differential cellular distribution of tonicity-induced expression of transcription factor TonEBP in the rat brain following prolonged systemic hypertonicity.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

We analyzed the induction of osmoprotective gene products in response to hypertonicity in proliferating T cells obtained by culturing splenocytes with the mitogen concanavalin A plus IL-2 during 72 hours.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In this regard, our comparison of a wild-type NFAT5 construct with a constitutively nuclear one suggested that nuclear localization alone without hypertonicity could cause a moderate transcriptional response.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

− / − lymphocytes exposed to pathologic hypertonicity.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

+ / + and NFAT5 − / − cells in response to hypertonicity.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

+ / + and p53 − / − T cells in response to hypertonicity.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

− / − lymphocytes after 8 hours of hypertonicity treatment.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

+ / + and NFAT5 − / − T cells after 8 and 24 hours of hypertonicity treatment.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

+ / + and NFAT5 − / − T cells in response to hypertonicity were analyzed by Western blot.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Paroxysmal hypertonicity disorder (also called episodic falling): a type of epilepsy in which the muscles are unable to relax.    From Wordnik.com.  [MyLinkVault Newest Links] Reference

− / − cells: one, we asked whether these cells displayed enhanced markers of genotoxic stress; and two, we analyzed how hypertonicity affected the expression of cell cycle regulators in wild-type and NFAT5.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

B) Transgenic 9×NFAT-Luc T cells were labeled with Hoechst 33342 and sorted after 8 and 24 hours of exposure to hypertonicity.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

DB1 and ND5DB1), which were comparably cytoplasmic in isotonic conditions, could translocate to the nucleus completely in response to hypertonicity (.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

B) mRNA abundance of cyclins was analyzed by RT-qPCR in proliferating NFAT5 + / + and NFAT5 − / − T cells subjected to hypertonicity for 8 and 24 hours.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In parallel experiments, we observed that NFAT5 − / − T cells exposed to hypertonicity during 24 hours exhibited poorer viability (56\%) than wild-type cells (70\%) (.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

NLS+AED) displayed a pancellular distribution in interphase, which was dependent only on its DNA binding capacity and was insensitive to hypertonicity (comparison between ND5.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

3) Defective expression of cyclins in hypertonicity-treated NFAT5.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

2) Induction of p53 and markers of genotoxic stress in hypertonicity-treated NFAT5.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

(1999) Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference