There are pancreatic and extrapancreatic factors in the production of hypophyseal diabetes.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

It is produced by the injection of hypophyseal extract, but persists without this treatment.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

Hepatectomy causes a rapid fall in the blood sugar of dogs or toads with a hypophyseal diabetes.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

Only the hypophyseal treatment produced lesions of the islets and decrease or absence of insulin secretion.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

The injection or implantation of anterior hypophyseal lobe reestablished or even increased the usual severity of diabetes.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

In hypophyseal insufficiency glucose formation by the liver does not increase during hypoglycemia as it does in normal animals.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

The diabetic conditions which persists when the hypophyseal treatment is discontinued, should be called metahypophyseal diabetes.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

It is possible that in acromegaly, in some stages of the disease there may be a hypophyseal diabetes and at others a metahypophyseal diabetes.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

Once in the pituitary, they determine the exact quantities of the various hypophyseal hormones which must be produced at a given point in time.    From Wordnik.com.  [The Nobel Prize in Physiology or Medicine 1977 - Presentation Speech] Reference

The diabetic condition which appears during hypophyseal treatment and which disappears when this treatment is discontinued should be called hypophyseal diabetes.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

In hypophyseal diabetes there is a marked increase in insulin resistance, while in metahypophyseal diabetes the resistance to the action of insulin is normal or only slightly increased.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

At this stage even if the hypophyseal treatment is discontinued the animals remain permanently diabetic, degeneration of the beta cells continues and the pancreas ceases to secrete insulin.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

Young has obtained a concentrated extract, but it has not been prepared in a pure form, so it is not yet possible to say if it is a separate hypophyseal hormone, different from those already known.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

A normal pancreas reestablishes the normal blood sugar level in three to five hours and maintains it there, while the pancreas taken from an animal in hypophyseal diabetes has little or no effect on the blood sugar.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

The experiments of Long show that the adrenocorticotrophic hormone of the hypophysis by releasing corticoadrenal hormones, plays a part in the diabetogenic effect; but my own experiments prove there is a hypophyseal diabetogenic action which takes place when there are no adrenals.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

Extrapancreatic: factors are demonstrated by: (1) the diabetogenic effect obtained in pancreatectomized hypophysectomized animals; (2) the increase in the severity of diabetes in pancreatectomized dogs treated with anterohypophyseal extract; (3) the increase in resistance to insulin which precedes and accompanies hypophyseal diabetes; (4) the fact that hyperglycemia and diabetes occur before that there are visible lesions in the beta cells of the islets, and before insulin secretion diminishes.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

Hind-brain.p. Original position of hypophyseal diverticulum, py. ph.    From Wordnik.com.  [Illustrations. Fig. 1182] Reference

The hypophyseal branches are one or two minute vessels supplying the hypophysis.    From Wordnik.com.  [VI. The Arteries. 3a. 4. The Internal Carotid Artery] Reference

The upwardly directed hypophyseal involution becomes applied to the antero-lateral aspect of a downwardly directed diverticulum from the base of the fore-brain (page 744).    From Wordnik.com.  [XI. Splanchnology. 4d. The Hypophysis Cerebri] Reference

The hypophysis (pituitary body) (Fig. 1180) is a small reddish-gray body, about 1 cm. in diameter, attached to the end of the infundibulum of the brain and resting in the hypophyseal fossa.    From Wordnik.com.  [XI. Splanchnology. 4d. The Hypophysis Cerebri] Reference

These integrations stimulate the brain-cells, the ductless glands, and other parts, and the energizing secretions, among which are epinephrin, thyroid and hypophyseal secretions, are thrown into the blood-stream, while that most available fuel, glycogen, is also mobilized in the blood.    From Wordnik.com.  [The Origin and Nature of the Emotions: Miscellaneous Papers] Reference

(4) pure growth hormone increases glycosuria in subtotally pancreatectomized rats; (5) the fixation of nitrogen caused by hypophyseal extract is conditioned by the amount of islet tissue or of insulin.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference