These complexes become attached to some of the spindle microtubules, which are then termed kinetochore microtubules.    From Wordnik.com. Reference

We now believe that proteins in a structure called the kinetochore are among the most sensitive to degradation or mutation.    From Wordnik.com.  [Science Blog - Science news straight from the source] Reference

Condensin dependent CENP-A loading and kinetochore integrity.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Aberrant kinetochore structure and function without condensin.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Models of the condensin-loss-mediated centromere and kinetochore dysfunction.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Left panel: Aurora B is properly localized and can reach its kinetochore substrates.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The actual contribution of condensins to centromere/kinetochore function is not understood.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In anaphase A shrinking kinetochore microtubules move the chromosomes towards the spindle poles.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

The insert schematic shows the arrangement of a merotelic kinetochore with attached microtubules.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Zinkowski RP, Meyne J, Brinkley BR (1991) The centromere-kinetochore complex: a repeat subunit model.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

SMC2-depleted HeLa cells stained with antibodies against BUB1 to visualize the inner kinetochore plate.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The most probable interface between condensin activity and kinetochore functions is centromeric chromatin.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

It is also unknown whether Aurora B functions after kinetochore assembly involves regulation of condensins.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Inserts show magnified images representing individual sister kinetochore pairs from single optical sections.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Al-Bassam J, Harrison SC (2007) The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In addition, the anchoring and stabilization of microtubules at the kinetochore plate is a late event of Meiosis I.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Positioning of the outer kinetochore component NDC80/HEC1, which makes direct contact with kinetochore microtubules.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Condensin depletion mimics the disruption of Aurora B activity in correcting kinetochore microtubule misattachments.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Both inner and outer kinetochore proteins are stretched/dispersed by spindle forces in metaphase upon SMC2 depletion.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Nevertheless, in condensin-depleted metazoan cells, targeting of centromere and kinetochore markers is largely normal.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The kinetochore protein Mtw1 was epitope-tagged, allowing us to score the number of kinetochore foci in spread nuclei.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Chd1 mutant fly embryos does not interfere with centromere and kinetochore assembly, as the levels and localization of CenH3.    From Wordnik.com.  [Elites TV] Reference

Condensin-deficient cells are proficient in the maintenance of the mitotic checkpoint in the absence of kinetochore tension.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

A similarly stretched morphology of the inner kinetochore (visualized by Xenopus BUB1 antibody) was observed in Xenopus laevis.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Condensin depletion results in extremely stretched centromeric chromatin disrupting kinetochore morphology identifiable by EM.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

This indicates that condensins-depleted cells have normal level of MAD2 response but delayed timing of full kinetochore attachment.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Waters JC, Mitchison TJ (2004) Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

During cell division microtubules capture chromosomes by binding to the kinetochore assembled in the centromeric region of chromosomes.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

The absence of most of kinetochore proteins is not surprising, as chromosomes should have sedimented during the extract clarification step.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The kinetochore microtubules shorten as the chromosomes are pulled toward the poles, while the polar microtubules elongate to assist in the separation.    From Wordnik.com. Reference

When the chromosomes have completely migrated to the spindle poles, the kinetochore microtubules begin to disappear, although the polar microtubules continue to elongate.    From Wordnik.com. Reference

Fig. 4), and in the dispersion of microtubule attachment sites within the single kinetochore (Fig. 8A).    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

B) A high incidence of syntelic mis-attachments of kinetochore microtubules in metaphase upon condensin depletion.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Double staining with kinetochore and centromere markers identified some merotelic pairs after condensin depletion (.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

So too is a high incidence of bent and deformed kinetochore plates, which coincide with microtubules projecting to both poles (.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

C) Condensins-deficient cells cannot maintain proper level of active Aurora B at kinetochores in the presence of kinetochore tension.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference