In consequence the new mineralocorticoid was named aldosterone (al-dos'ter-ohn). From Wordnik.com. [The Human Brain]
Aldosterone is also unusual, for a mineralocorticoid, in possessing an oxygen at carbon-n. From Wordnik.com. [The Human Brain]
In 1953, more than a decade after the discovery of four important glycocorticoids and two important mineralocorticoids, there came the rather surprising isolation of another mineralocorticoid. From Wordnik.com. [The Human Brain]
Why this should be we cannot yet tell, but this point of putting the oxygen on, then neutralizing it, results in a mineralocorticoid that is much more powerful than any of those in which the oxygen is absent in the first place. From Wordnik.com. [The Human Brain]
K+ deprivation potentiates the renal alkalosis producing effect of mineralocorticoid. From Wordnik.com. [Citizendium, the Citizens' Compendium - Recent changes [en]] Reference
Effects of dietary potassium depletion and mineralocorticoid excess on renal Cl conservation in the dog. From Wordnik.com. [Citizendium, the Citizens' Compendium - Recent changes [en]] Reference
The null mice exhibited glucocorticoid deficiency, mineralocorticoid excess, adrenal hyperplasia, mild hypertension, and hypokalemia. From Wordnik.com. [Journal of Biological Chemistry current issue] Reference
De Bono said patients taking abiraterone generally avoided the unpleasant side-effects associated with chemotherapy, although they did have more mineralocorticoid-related side effects. From Wordnik.com. [Yahoo! News: Business - Opinion] Reference
In in vitro binding affinity and functional assays neither of these compounds have affinity for the progesterone (PR), estrogen (ER), androgen (AR) or mineralocorticoid (GR-I) receptors. From Wordnik.com. [Corcept Therapeutics Announces Third Quarter Results and Corporate and Development Update - Yahoo! Finance] Reference
A 35 year old woman was taking life long glucocorticoid (dexamethasone) and mineralocorticoid (fludrocortisone, Florinef, Squibb) replacement for congenital adrenal hyperplasia caused by 21-hydroxylase deficiency. From Wordnik.com. [BMJ Latest Articles] Reference
Patients with congenital adrenal hyperplasia arising from mutations of 11β-hydroxylase, the final enzyme in the glucocorticoid biosynthetic pathway, exhibit glucocorticoid deficiency, adrenal hyperplasia driven by unsuppressed hypothalamo-pituitary-adrenal activity, and excess mineralocorticoid activity caused by the accumulation of deoxycorticosterone. From Wordnik.com. [Journal of Biological Chemistry current issue] Reference
(estrogen), AR (androgen) or GR-I (mineralocorticoid) receptors. From Wordnik.com. [StreetInsider.com News Articles] Reference
But we know that it does act that way in modern fish (Sturm A, Bury N, Dengreville L, Fagart J, Flouriot G, Rafestin-Oblin ME, Prunet P. 11-deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss mineralocorticoid receptor. From Wordnik.com. [Evolution of IC: Evolution of Hormone-Receptor Complexity - The Panda's Thumb] Reference
Several other markers had DNA binding and / or transcription factor (TF) activity, including a calmodulin-binding TF (CAMTA1), a repressor of TF activity (DIP2A), a mineralocorticoid receptor (NR3C2), a member of the myc family (MYCN), and two homeobox genes. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
8l This new mineralocorticoid had an unusual structure, too. From Wordnik.com. [The Human Brain]
Fig. 2B), and a mineralocorticoid receptor (NR3C2) were enriched in HVC, as were three genes with known androgen-related action, namely, an androgen-sensitive regulator of G-proteins (RGS4), which was enriched in HVC, and an androgen-induced prostate cancer RNA (TMEPAI) and an androgen regulated FERM domain containing protein (EPB41L2), which had lower expression in HVC. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
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