One of the big concerns, actually, from these bites is that the skin surrounding the bite might actually die or necrose.    From Wordnik.com.  [CNN Transcript Feb 9, 2003] Reference

So far, when introducing these sugars for a few weeks or months, they are seeing the body produce stem cells (new ones actually visible in the blood stream!) to rebuild damaged nerves, secrete a substance naturally made as a result of one of these sugars being ingested, which causes cancerous tumours to necrose, turn black, and break down (!!), fight off the AIDS and HIV viruses, and further incredible stuff.    From Wordnik.com.  [sheepdip Diary Entry] Reference

After a while, the tissue begins to necrose (die).    From Wordnik.com.  [The Acorn] Reference

There are also bacilli that are capable of multiplying in tissues and so irritating them as to cause them to die (necrose) without forming pus.    From Wordnik.com.  [Special Report on Diseases of the Horse] Reference

(necrose) from want of blood and cause a serious quittor, or fistula.    From Wordnik.com.  [Special Report on Diseases of the Horse] Reference