Researchers at the Tulane University School of Medicine, New Orleans, Louisiana have discovered that the HIV-1 protease inhibitors (PIs), such as nelfinavir included in highly active antiretroviral therapy (HAART) regimen for the treatment of HIV-1 patients, induce deleterious effects on insulin secretion mediated through the oxidative stress pathway.    From Wordnik.com.  [PhysOrg.com - latest science and technology news stories] Reference

Therapies which included nelfinavir (Viracept), amprenavir.    From Wordnik.com.  [ANC Daily News Briefing] Reference

And Agouron Pharmaceuticals will soon seek approval for nelfinavir, the first protease inhibitor formulated for children as well as adults.    From Wordnik.com.  [Targeting A Deadly Scrap Of Genetic Code] Reference

In August 2001, Brazilian Health Minister Jose Serra announced the Brazilian government would issue a compulsory license for the manufacture of the antiretroviral drug nelfinavir, whose brand name was Viracept.    From Wordnik.com.  [Robert Naiman: Brazil Should Lead on Access to Essential Medicines] Reference

In the U.S. trial, a further drug - nelfinavir - was combined with lamivudine and AZT, and appeared to not only slow progression to the full-blown disease but to reduce the levels of the HIV virus in the blood, Lancet reported.    From Wordnik.com.  [ANC Daily News Briefing] Reference

Volunteers in the second study received the protease inhibitor nelfinavir.    From Wordnik.com.  [Health News from Medical News Today] Reference

Ask your kremers urban omeprazole care muscle if nelfinavir powder may interact with carotid subjects that you take.    From Wordnik.com.  [Wii-volution] Reference

Indeed pretreatment of pancreatic beta-cells with thymoquinone caused a reversal of nelfinavir induced deleterious effects.    From Wordnik.com.  [PhysOrg.com - latest science and technology news stories] Reference

Pfizer is advising healthcare professionals to avoid treating certain children and pregnant women with the antiretroviral drug Viracept (nelfinavir mesylate).    From Wordnik.com.  [WN.com - Articles related to Novartis employees across Canada join global colleagues for 14th annual Community Partnership Day] Reference

However, the mitochondrial uncoupling protein (UCP2) levels were up-regulated during nelfinavir induced oxidative stress and directly affected the ATP levels in these cells.    From Wordnik.com.  [PhysOrg.com - latest science and technology news stories] Reference

Kharasch ED, Walker A, Whittington D, Hoffer C, Sheffels Bedynek P. Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity.    From Wordnik.com.  [Health News from Medical News Today] Reference

In these studies, Kharasch and his team looked at interactions among methadone, the P4503A enzyme in the intestine and liver and the protease inhibitors nelfinavir, indinavir and ritonavir.    From Wordnik.com.  [Health News from Medical News Today] Reference

The simulation included isopropanol solvent recovery from the manufacture of nelfinavir, the active ingredient in the antiretroviral drug VIRACEPT®, used in the treatment of the human immunodeficiency virus (HIV).    From Wordnik.com.  [Newswise: Latest News] Reference

One of the products produced at the site is Pfizer's HIV drug Viracept (nelfinavir) but today the scientists and staff focus on discovering and developing new medicines to treat different forms of cancer and diseases of the eye.    From Wordnik.com.  [DrugResearcher RSS] Reference

They report a significant decrease in the levels of the antioxidants, cytosolic superoxide dismutase (Cu / Zn SOD) and glutathione, whereas mitochondrial SOD levels remained unaffected in pancreatic beta-cells (INS-1 cells) exposed to nelfinavir.    From Wordnik.com.  [PhysOrg.com - latest science and technology news stories] Reference

Thymoquinone decreased the production of reactive oxygen species, increased the Cu / Zn SOD and glutathione levels, suppressed the UCP-2 protein levels and restored nelfinavir induced decrease in insulin secretion to normal levels in these cells.    From Wordnik.com.  [Health News from Medical News Today] Reference

These investigators successfully tested the hypothesis that nelfinavir induced oxidative stress was responsible for the deleterious effects of the HIV-1 protease inhibitor on insulin production by pancreatic beta-cells and they further investigated the therapeutic strategies to ameliorate the insulin dysregulation at this level.    From Wordnik.com.  [Health News from Medical News Today] Reference

"thymoquinone, an antioxidant provided a significant protection to pancreatic beta-cells from the toxic effects of nelfinavir and therefore these findings clearly suggest a potential role for the use of black seed oil or thymoquione as a protective agent against HIV-1 protease inhibitor induced deleterious effects on pancreatic beta-cells".    From Wordnik.com.  [PhysOrg.com - latest science and technology news stories] Reference

(PIs: NFV - nelfinavir, ATV - atazanavir, LPV - lopinavir, RTV - ritonavir, IDV - indinavir.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

(Norvir), or nelfinavir (Viracept).    From Wordnik.com.  [Wii-volution] Reference

100mg/kg of nelfinavir (NFV), indinavir (IDV), didanosine (DDI) or 50mg/kg of zidovudine.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

2.5 mg/1000 mg once daily when coadministered with a strong CYP3A4/5 inhibitor e.g., atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin.    From Wordnik.com.  [KOMBIGLYZE™ XR (Saxagliptin and Metformin HCl Extended-Release) Tablets, a New Treatment for Type 2 Diabetes Mellitus in Adults, Now Available in U.S. Pharmacies - Yahoo! Finance] Reference

Do yet abbott erythromycin this potency without drying your colitis if you are breast-feeding a baby. 45 with a would erythromycin kill fungus antibiotic (eg, erythromycin, clarithromycin, troleandomycin), hiv side inhibitor (eg, ritonavir, nelfinavir, indinavir, amprenavir, saquinavir), or function spinal (eg, ketoconazole, itraconazole).    From Wordnik.com.  [Wii-volution] Reference

Fentanyl transdermal system with all cytochrome P450 3A4 inhibitors such as ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, nefazodone, amiodarone, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, and verapamil may result in an increase in fentanyl plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression.    From Wordnik.com. Reference

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