When nondisjunction occurs, the resulting eggs may carry too few or too many chromosomes, a state called aneuploidy. From Wordnik.com. [Delayed Childbearing] Reference
Embryos that are trisomic contain, instead of matched pairs of chromosomes, one too many of a given chromosome, most commonly chromosome 13, 18, 21 (which is responsible for Down syndrome), X, or Y. Trisomies are the result of a glitch known as nondisjunction, which occurs principally during the creation of egg cells (although sperm cells may also exhibit such errors). From Wordnik.com. [Delayed Childbearing] Reference
Koehler KE, Hawley RS, Sherman S, Hassold T (1996) Recombination and nondisjunction in humans and flies. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Shi Q, King RW (2005) Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Shi Q, King R. W (2005) Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. From Wordnik.com. [PLoS Biology: New Articles] Reference
This makes sense, since these cancers often fail to inactivate the X chromosome, and X chromosome nondisjunction leads to more male worms. From Wordnik.com. [Ars Technica]
Thus, condensin dysfunction synergistically induces merotelic attachments and compromises the merotelic attachment correction mechanism, leading to chromosome breaks and nondisjunction. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Most of what goes wrong during meiosis-to-fertilization-to-mitosis results in chromosomal abnormalities, usually nondisjunction, thus providing a mechanism for aneuplodiy -- rather than an insistence that it really does happen. From Wordnik.com. [WN.com - Articles related to Plants give up some deep secrets of drought resistance] Reference
The results described here indicate that dysfunction of human condensin both compromises an important controlling mechanism (correction of syntelic and merotelic attachments) and leads to chromosome damage (breaks) and nondisjunction. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Later, in telophase, this nondisjunction is apparently resolved via putative chromosomal breaks, which were identified by appearance of the foci of phosphorylated histone H2AX (. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
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