Slide 26: (OPG), also known as osteoclast inhibitory factor (OCIF) is a soluble decoy receptor for RANKL (111).    From Wordnik.com.  [Recently Uploaded Slideshows] Reference

Incidentally, osteoclast is a type of cell that attacks the bone.    From Wordnik.com.  [CNN Transcript May 3, 2007] Reference

Activated T lymphocytes support osteoclast formation in vitro.    From Wordnik.com.  [Recently Uploaded Slideshows] Reference

RANKL expression, but in certain conditions may increase osteoclast activity.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

It has been demonstrated that estrogen loss significantly affect osteoclast formation.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Teitelbaum S, Ross FP (2003) Genetic regulation of osteoclast development and function.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

KO mice we performed histomorphometric measurements of osteoblast and osteoclast activity.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

These mice revealed a time course of cartilage damage and osteoclast-mediated bone resorption.    From Wordnik.com.  [THE MEDICAL NEWS] Reference

An osteoblast engaged in the absorption instead of the formation of bone is called an osteoclast.    From Wordnik.com.  [Text Book of Biology, Part 1: Vertebrata] Reference

Measurements of osteoclast activity did not show any differences in femurs from mice of any genotype.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Trolox also suppressed interleukin-1-induced osteoclast formation and bone loss in mouse calvarial bone.    From Wordnik.com.  [Journal of Biological Chemistry current issue] Reference

Measurements of osteoclast activity did not show any differences in femurs from mice of any genotype either.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

They found that expression of IRF-8 was reduced by 75 percent in the initial phases of osteoclast development.    From Wordnik.com.  [THE MEDICAL NEWS] Reference

Wong BR, Josien R, Choi Y. TRANCE is a TNF family member that regulates dendritic cell and osteoclast function.    From Wordnik.com.  [Recently Uploaded Slideshows] Reference

Alendronate does not interfere with osteoclast recruitment or attachment, but it does inhibit osteoclast activity.    From Wordnik.com. Reference

The tumors consist of sheets of neoplastic ovoid mononuclear cells evenly interspersed with osteoclast-like giant cells.    From Wordnik.com.  [MedPageToday.com - medical news plus CME for physicians] Reference

Prolia is being investigated for its potential to inhibit all stages of osteoclast activity through a targeted mechanism.    From Wordnik.com.  [Medlogs - Recent stories] Reference

Denosumab is being investigated for its potential to inhibit all stages of osteoclast activity through a targeted mechanism.    From Wordnik.com. Reference

Denosumab is an experimental osteoclast-targeted monoclonal antibody against receptor activator of nuclear factor-κB ligand.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

The Mundy/Raisz '' osteoclast activating factor '' - OAF - became the byword for how blood cancers could affect the skeleton.    From Wordnik.com.  [The Age News Headlines] Reference

Thus we investigated (paper IV) synovial expression of OPG and RANKL, considered as main denominators of osteoclast activity.    From Wordnik.com.  [Recently Uploaded Slideshows] Reference

This makes sense given that upregulation of NFATc1 is involved in triggering osteoclast precursor cells to turn into osteoclasts.    From Wordnik.com.  [THE MEDICAL NEWS] Reference

Denosumab targets the receptor activator of NF-B ligand (RANKL), which mediates osteoclast function and hence bone destruction.    From Wordnik.com.  [Medlogs - Recent stories] Reference

Tnfrsf11b, the gene encoding the osteoclast-inhibitory factor Opg, is known to be induced by canonical Wnt signaling in osteoblasts.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Glycosaminoglycan-mediated loss of cathepsin K collagenolytic activity in MPS I contributes to osteoclast and growth plate abnormalities.    From Wordnik.com.  [Health News from Medical News Today] Reference

Dr. Ishii worked with Dr. Germain's lab to determine if a specific chemical mediator controlled immature osteoclast migration in live mice.    From Wordnik.com.  [National Institutes of Health (NIH) News Releases] Reference

An osteoblast is a type of cell that is responsible for forming bone and an osteoclast is a type of cell that breaks down bony tissue (bone resorption).    From Wordnik.com.  [THE MEDICAL NEWS] Reference

Balintfy: In people with bone-destructive disorders such as osteoporosis, however, osteoclast activity outpaces osteoblast activity, leading to a loss of bone density.    From Wordnik.com.  [National Institutes of Health (NIH) News Releases] Reference

Denosumab works by inhibiting RANKL, which regulates osteoclast activity and function and has been linked with increased bone loss and complications from bone metastases.    From Wordnik.com.  [Newswise: Latest News] Reference

This included a study that showed that silencing IRF-8 messenger RNA in human osteoclast precursors with small interfering RNAs resulted in enhanced osteoclast production.    From Wordnik.com.  [THE MEDICAL NEWS] Reference

As osteoclast activation is associated with disease progression, skeletal complications and death, osteoclast-targeted therapies are a rational approach to disease management.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

1,2 decrease osteoclast-mediated bone resorption and bone turnover markers and increase bone mineral density.    From Wordnik.com.  [Medlogs - Recent stories] Reference