Preclinical studies also suggest that Vimpat® binds to the collapsin response mediator protein-2 (CRMP-2), a phosphoprotein which is mainly expressed in the nervous system and is involved in neuronal differentiation and control of axonal outgrowth. From Wordnik.com. [Marketwire - Breaking News Releases] Reference
However, what you ask in your ROC plot is not whether each phosphorylation site is correct but whether the protein is a phosphoprotein. From Wordnik.com. [Prediction of phospho-proteins from sequence] Reference
In order to properly control for this observation I calculated the correlation observed in figure 1 randomizing the phosphorylation sites within each phosphoprotein. From Wordnik.com. [Translationally optimal codons do not appear to significantly associate with phosphorylation sites] Reference
To compare I also randomized the phosphorylation sites keeping the total number of phosphorylation sites fixed but not restricting the number of phosphorylation sites within each specific phosphoprotein. From Wordnik.com. [Translationally optimal codons do not appear to significantly associate with phosphorylation sites] Reference
The observed correlation would appear to be significantly higher than random if we allow the random phosphorylation sites to be drawn from any phosphoprotein without constraining the number of phosphorylation sites in each specific protein blue curve. From Wordnik.com. [Translationally optimal codons do not appear to significantly associate with phosphorylation sites] Reference
When randomizing the phosphorylation sites within each phosphoprotein, keeping the number of phosphorylation sites in each specific phosphoproteins constant the average R-squared is higher than the observed with the experimentally determined phosphorylation sites pink curve. From Wordnik.com. [Translationally optimal codons do not appear to significantly associate with phosphorylation sites] Reference
Paramyxoviridae encode a nucleoprotein (N), a phosphoprotein (P), a matrix protein (M). From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
The phosphoprotein (P) gene contains a conserved RNA editing site and is predicted to encode P, V, and W proteins. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
We show that FoxA2, found to be a phosphoprotein in vivo, is also an efficient substrate for DNA-PK, which targets serine 283. From Wordnik.com. [Journal of Biological Chemistry current issue] Reference
Researchers use our products to discover subtle details about phosphoprotein signaling in a wide variety of biological systems. From Wordnik.com. [SiliconIndia.com] Reference
(A) Kinetworks ™ phosphoprotein immunoblots from lysates of Caco-2 / TC7 cells cultured on filters without micelles (control) or with PPM or IPM for 5 min. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Kalaitzidis D, Neel BG (2008) Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
ITI-007 is the Company's first-in-class 5-HT2A receptor antagonist/dopamine receptor phosphoprotein modulator (DPPM)/serotonin reuptake inhibitor for the treatment of schizophrenia. From Wordnik.com. [Health News from Medical News Today] Reference
Bratlid D, Walaas SI (1988) Bilirubin decreases phosphorylation of synapsin I, a synaptic vesicle-associated neuronal phosphoprotein, in intact synaptosomes from rat cerebral cortex. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Inhibition of platelet aggregation was measured using three separate methods: VerifyNow P2Y12 assay, light transmission aggregometry, and phosphorylation of vasodilator stimulated phosphoprotein. From Wordnik.com. Reference
Today launched a service program to provide phosphoprotein analysis of pre-clinical samples for vaccine to protect against 2009 influenza A (H1N1) virus, a Rice. From Wordnik.com. [WN.com - Articles related to Quake survivors 'need years of aid'] Reference
I do recall reading in a biochemistry page on cholesterol synthesis how both glucagon and epinephrine (adrenaline) negatively affect cholesterol biosynthesis by inhibiting phosphoprotein phosphate-1 (PPI-1)–but it’s not tying in flawlessly… any thoughts appreciated. From Wordnik.com. [Best seller list July 1-Sep 30, 2007 | The Blog of Michael R. Eades, M.D.] Reference
NC, 1: 1,000) or dopamine - and cAMP-regulated phosphoprotein polypeptide (DARPP-32, Chemicon. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
The nuclear phosphoprotein MYC (V-MYC avian myelocytomatosis viral oncogene homolog) was 9 fold induced and was central to the highest scored network that included induction of 3 subunits of eukaryotic translation initiation factor 3 (. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
(2003) The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Other examples of profoundly (over 20-fold) upregulated genes included interferon induced transmembrane protein 2 (IFITM2), insulin-like growth factor binding protein 1 (IGFBP1), CD5 molecule-like (CD5L), lymphocyte cytosolic protein 2, CD48, thrombospondin 4, secreted phosphoprotein 1 (osteopontin), CD163, membrane-spanning 4-domains, subfamily A, member 7 (MS4A7) and Growth-associated protein-43. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
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