In contrast to their mammalian hosts, platyhelminth (flatworm) parasites studied so far, lack conventional thioredoxin and glutathione systems.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

In contrast, the free-living platyhelminth Schmidtea mediterranea (Class Turbellaria) possesses conventional and linked thioredoxin and glutathione systems.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

platyhelminth parasites possess a unique and simplified redox system for diverse essential processes, and thus TGR is an excellent drug target for platyhelminth infections.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

Mushroom bodies are prominent neuropils involved in the processing of multiple sensory inputs as well as associative learning in the insect, platyhelminth, and annelid brains.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

We also provide experimental evidence that alternative initiation of transcription and alternative transcript processing contribute to the generation of TGR variants in platyhelminth parasites.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

Little is known regarding the genomic structure of flatworm TGRs, the expression of TGR variants and whether the absence of conventional thioredoxin and glutathione systems is a signature of the entire platyhelminth phylum.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

TGR has been recently validated as a drug target for schistosomiasis and new drug leads targeting TGR have recently been identified for these platyhelminth infections that affect more than 200 million people and for which a single drug is currently available.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

We examine platyhelminth genomes and transcriptomes and find that all platyhelminth parasites (from classes Cestoda and Trematoda) conform to a biochemical scenario involving, exclusively, a selenium-dependent linked thioredoxin-glutathione system having TGR as a central redox hub.    From Wordnik.com.  [BioMed Central - Latest articles] Reference