In the final stages of "cell dying", the nucleus becomes shrunken (pyknosis) or fragmented (karyorrhexis). From Wordnik.com. [Cell damage from toxicity and tissue repair] Reference
This is confirmed by characteristic DNA fragmentation, nuclear shrinkage (pyknosis), and nuclear fragmentation (karyorrhexis), which is demonstrated by DA PI in apoptotic round cells. From Wordnik.com. [Organic Consumers Association News Headlines] Reference
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