Canada have detected a novel oncolytic viral therapy against prostate cancer with use of a virus called the reovirus. From Wordnik.com. [WN.com - Articles related to Parents puff gives children asthma, doctors warn] Reference
Researchers in Canada have detected a novel oncolytic viral therapy against prostate cancer with use of a virus called the reovirus, according to study results published in Cancer Research, a journal of the American Association for Cancer Research. From Wordnik.com. [RedOrbit News - Technology] Reference
The respiratory, enteric, orphan virus (commonly known as reovirus) is a non-attenuated, environmental virus that has shown oncolytic potential against many types of cancer, specifically lymphoid, ovarian, breast, pancreatic and high grade glioma cancer, according to the study. From Wordnik.com. [RedOrbit News - Technology] Reference
"The reovirus is a very common, ubiquitous virus that most people are exposed to. From Wordnik.com. [RedOrbit News - Technology] Reference
Activated Ras signaling significantly enhances reovirus replication and spread. From Wordnik.com. [Naturejobs - All Jobs] Reference
Research study supports reovirus and cisplatin combination for cancer treatment. From Wordnik.com. [THE MEDICAL NEWS] Reference
The virus is called the respiratory, enteric, orphan virus - shortened to reovirus. From Wordnik.com. [Home | Mail Online] Reference
Combination of reovirus and carboplatin/paclitaxel shows promising anticancer activity in. From Wordnik.com. [THE MEDICAL NEWS] Reference
The reovirus (Respiratory Enteric Orphan virus) is the main target of investigation here. From Wordnik.com. [Softpedia News - Global] Reference
Enter REOLYSIN®, an experimental treatment derived from a common virus called the reovirus. From Wordnik.com. [Health News from Medical News Today] Reference
However, unlike the in vitro observations, the combination of rapamycin and reovirus is synergistic in vivo. From Wordnik.com. Reference
REOLYSIN is a proprietary formulation of the human reovirus that acts primarily as a direct cytotoxic agent. From Wordnik.com. [The Earth Times Online Newspaper] Reference
Cancer researcher Dr. Patrick Lee has proven that human reovirus can infect and kill breast cancer stem cells. From Wordnik.com. [SuperStrain Biosecurity Blog] Reference
Specifically, Oncolytics is testing a live cancer biologic called REOLYSIN®, which is derived from the human reovirus. From Wordnik.com. [Best Syndication -] Reference
Previous research has shown that reovirus has '' oncolytic '' potential, meaning it preferentially targets cancer cells. From Wordnik.com. [Telegraph.co.uk: news, business, sport, the Daily Telegraph newspaper, Sunday Telegraph] Reference
BHK-21 cells are susceptible to human adenovirus D, reovirus 3, and vesicular stomatitis virus (Indiana strain), but are resistant to poliovirus 2. From Wordnik.com. Reference
The line is susceptible to a number of viruses, including Meleagrid herpes virus 1, fowlpox virus, reovirus, avian sarcoma leukemia virus, and Rous sarcoma virus. From Wordnik.com. Reference
But the reovirus can replicate only in cancer cells with mutations along a signaling pathway in the cell called the Ras pathway, while leaving normal cells unharmed. From Wordnik.com. [THE MEDICAL NEWS] Reference
"For the treatment of localized prostate cancer, we found that the reovirus is safe and has evidence of specific tumor vs. normal prostate cell efficacy," added Morris. From Wordnik.com. [RedOrbit News - Technology] Reference
Using preclinical and clinical settings, Morris and colleagues examined the efficacy of the reovirus as an experimental therapeutic for prostate cancer in vitro and in vivo. From Wordnik.com. [RedOrbit News - Technology] Reference
Interestingly, the combination of reovirus and paclitaxel was uniformly synergistic in all six NSCLC cell lines examined, including in those resistant to paclitaxel or reovirus. From Wordnik.com. [Health News from Medical News Today] Reference
'' For the treatment of localised prostate cancer, we found that the reovirus is safe and has evidence of specific tumour versus normal prostate cell efficacy, '' said Dr Morris. From Wordnik.com. [Telegraph.co.uk: news, business, sport, the Daily Telegraph newspaper, Sunday Telegraph] Reference
'It is also unclear whether reovirus would be useful for the treatment of all types of prostate tumour as it is not entirely evident how it distinguishes cancers from other cells.'. From Wordnik.com. [Home | Mail Online] Reference
Oncolytics 'clinical program includes a variety of human trials including a Phase III trial in head and neck cancers using REOLYSIN, its proprietary formulation of the human reovirus. From Wordnik.com. Reference
Oncolytics 'clinical program includes a variety of human trials including a Phase III trial in head and neck cancers using REOLYSIN (R), its proprietary formulation of the human reovirus. From Wordnik.com. [BioSpace.com Featured News and Stories] Reference
"People have known of this application of the reovirus in trials, but no one to my knowledge has conducted studies in prostate cancer," said Clarke, who was not associated with this study. From Wordnik.com. [RedOrbit News - Technology] Reference
The investigators concluded that the immune response is critical to reovirus tumor therapy and is of direct translational relevance to fulfilling the potential of this novel anti-cancer agent. From Wordnik.com. Reference
Professor Robert Clarke, a member of the journal's editorial board, said: 'People have known of this application of the reovirus in trials, but no-one to my knowledge has conducted trials in prostate cancer. From Wordnik.com. [Home | Mail Online] Reference
Professor Robert Clarke, a member of the journal's editorial board, said: '' People have known of this application of the reovirus in trials, but no-one to my knowledge has conducted trials in prostate cancer. From Wordnik.com. [Telegraph.co.uk: news, business, sport, the Daily Telegraph newspaper, Sunday Telegraph] Reference
Oncolytics 'clinical program includes a variety of Phase I / II and Phase II human trials using REOLYSIN, its proprietary formulation of the human reovirus, alone and in combination with radiation or chemotherapy. From Wordnik.com. [The Earth Times Online Newspaper] Reference
Oncolytics 'clinical program includes a variety of Phase I / II and Phase II human trials using REOLYSIN (R), its proprietary formulation of the human reovirus, alone and in combination with radiation or chemotherapy. From Wordnik.com. [GEN News Highlights] Reference
Viruses that MDCK cells are susceptible to include vesicular stomatitis (Indiana strain), vaccinia, coxsackievirus B5, reovirus 2 and 3, adenovirus 4 and 5, vesicular exanthema of swine, and infectious canine hepatitis. From Wordnik.com. Reference
The cells, which appear to senesce after approximately 40 passages, are susceptible to herpes simplex, reovirus 3, vesicular stomatitis (Ogden strain), and vaccinia, but resist adenovirus 5, coxsackievirus A9 and B5, and poliovirus 2. From Wordnik.com. Reference
The investigators concluded that in vitro synergy between rapamycin and reovirus is only seen when rapamycin is administered after reovirus, and that simultaneous administration of rapamycin and reovirus decreases apoptotic cell death and viral replication. From Wordnik.com. Reference
Reolysin, an experimental treatment derived from a reovirus that replicates so prolifically in a cancer cell it causes the cell to burst, directly kills many types of cancer cells but leaves normal cells unharmed and works synergistically with other cancer therapies. From Wordnik.com. [Latest News - UPI.com] Reference
"Previous preclinical data indicates that reovirus tends to localize in the lungs, and we have seen clinical responses in metastatic lung lesions with REOLYSIN as a monotherapy or in combination with paclitaxel and carboplatin," said Dr. Brad Thompson, President and CEO of Oncolytics. From Wordnik.com. [Health News from Medical News Today] Reference
D. Sc., professor of oncology at Lombardi Comprehensive Cancer Center at Georgetown University and an editorial board member of Cancer Research, agreed, stating that he believes this study is worthy of subsequent clinical trials of the reovirus as a possible way of treating some prostate cancers. From Wordnik.com. [RedOrbit News - Technology] Reference
Check out the handsome reovirus core. From Wordnik.com. [Rambles at starchamber.com » Blog Archive » Virusworld] Reference
Oncolytics Biotech Inc. announced today that abstracts covering clinical research with reovirus (REO. From Wordnik.com. [THE MEDICAL NEWS] Reference
LearnThatWord and the Open Dictionary of English are programs by LearnThat Foundation, a 501(c)3 nonprofit.
Questions? Feedback? We want to hear from you!
Email us
or click here for instant support.
Copyright © 2005 and after - LearnThat Foundation. Patents pending.