A second estimation of essentiality, the Gene Conservation Score (GCS), was calculated on the basis of phyletic conservation of genes across Wolbachia's parent order Rickettsiales. From Wordnik.com. [BioMed Central - Latest articles] Reference
Although the order Rickettsiales has been proposed as the alpha - proteobacterial sister-group of mitochondria, there is no definitive evidence as to from which alpha - proteobacterial group the proto-mitochondrion emerged. From Wordnik.com. [Citizendium, the Citizens' Compendium - Recent changes [en]] Reference
Comparison of the MHS to GCS produces quadrants representing four types of predictions: those with high confidence of essentiality by both methods (245 genes), those highly conserved across Rickettsiales (299 genes), those similar to distant essential genes (8 genes), and those with low confidence of essentiality (253 genes). From Wordnik.com. [BioMed Central - Latest articles] Reference
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