In addition, increased sarcolemmal permeability suggests functional impairment of the DGC complex in cardiac myofibers. From Wordnik.com. [Naturejobs - All Jobs] Reference
In order to allow trans-sarcolemmal calcium to reach the intracellular ryanodine receptors, Cav1. 2 channels must be localized at T-tubules. From Wordnik.com. [PLoS Biology: New Articles] Reference
Utrophin's sarcolemmal expression was demonstrated in the muscle from one of the CKCS dogs in the current study in some non-regenerating fibres. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
The morphological alterations are heralded by sarcolemmal damage, characterized by increased plasma membrane permeability caused by oxidative damage to lipids and proteins. From Wordnik.com. [Naturejobs - All Jobs] Reference
Trans-sarcolemmal calcium entry and activation of ryanodine receptors is a local phenomenon and, in cardiomyocytes, sarcolemmal Cav1. 2 channels occur within 15 nm of their respective ryanodine receptors on the SR. From Wordnik.com. [PLoS Biology: New Articles] Reference
To rule out that the sarcolemmal invaginations themselves and not BIN1 are sufficient for Cav1. 2 delivery, we created C-terminal truncated BIN1, which fails to attract Cav1. 2 yet still inducing membrane invagination. From Wordnik.com. [PLoS Biology: New Articles] Reference
The researchers said that "sarcolemmal KATP channels govern muscle energy economy, and their downregulation in a tissue-specific manner could present an anti-obesity strategy by rendering muscle increasingly thermogenic at rest and less fuel efficient during exercise.". From Wordnik.com. [Gaea Times (by Simple Thoughts) Breaking News and incisive views 24/7] Reference
Separate experiments examined whether verapamil, which blocks the sarcolemmal voltage-operated Ca++ channel (Series 3), SK&F 96365 an inhibitor of sarcolemmal voltage-independent Ca++ channels (Series 4A+B), or ryanodine an inhibitor of the sarcoplasmic reticulum Ca++ channel. From Wordnik.com. [BioMed Central - Latest articles] Reference
The critical importance of the dystrophin-glycoprotein complex (DGC) in maintaining sarcolemmal stability led us to hypothesize that loss of dystrophin and associated glycoproteins could be involved in early increased sarcolemmal permeability in experimentally induced septic cardiomyopathy. From Wordnik.com. [Naturejobs - All Jobs] Reference
Consonantly, the evaluation of plasma membrane permeability by intracellular albumin staining provided evidence of severe injury of the sarcolemma in SSI hearts, whereas antioxidant treatment significantly attenuated the loss of sarcolemmal dystrophin expression and the increased membrane permeability. From Wordnik.com. [Naturejobs - All Jobs] Reference
Is to bring the channels into close proximity of the ryanodine receptors, amplifying sarcolemmal calcium entry to a large calcium release from the SR. From Wordnik.com. [PLoS Biology: New Articles] Reference
Myocardial ischemia is unlikely, as coronary blood flow is normal and there is no net lactate production across the coronary vascular bed. 130,131 Animal studies of endotoxemia or bacterial infection have suggested that myocardial edema,132 alterations in sarcolemmal or intracellular calcium homeostasis,133 and uncoupling or disruption of ß-adrenergic signal transduction may contribute to the cardiac contractile dysfunction. 134 A variety of inflammatory mediators, including prostanoids,135 platelet-activating factor,136 tumor necrosis factor (TNF) - α, interleukin (IL) -1 and IL-2, 137 and nitric 17. From Wordnik.com. [Recently Uploaded Slideshows] Reference
Disruption of sarcolemmal dystrophin and β. From Wordnik.com. [Naturejobs - All Jobs] Reference
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