The sarcomere is the primary functional unit of cardiac muscle that is responsible for contraction and force generation. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Investigations on the organ, tissue, and sarcomere levels. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Mutations in sarcomere protein genes in left ventricular non-compaction. From Wordnik.com. [Clinical Data, Inc. Launches FAMILION® Genetic Tests for Left Ventricular Noncompaction and Long QT Syndrome Large Deletion/Duplication Mutations - Yahoo! Finance] Reference
Muscle activity takes place in the smallest unit of muscle fiber, the sarcomere. From Wordnik.com. [PhysOrg.com - latest science and technology news stories] Reference
Muscle activity takes place in the smallest unit of muscle fibre, the sarcomere. From Wordnik.com. [Gaea Times (by Simple Thoughts) Breaking News and incisive views 24/7] Reference
CK-2017357 is the first small molecule sarcomere activator to reach clinical trials. From Wordnik.com. [SeekingAlpha.com: Home Page] Reference
Myofibrils are composed of a repetitiono f a specific sequence of units calleda sarcomere. From Wordnik.com. [CreationWiki - Recent changes [en]] Reference
The direction of thin filament movement during sarcomere shortening is toward the observer. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
It is currently unknown if cTnC has ordered or stochastic incorporation into the sarcomere. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
A sarcostyle may be said to be made up of successive portions, each of which is termed a sarcomere. From Wordnik.com. [IV. Myology. 2. Development of the Muscles] Reference
Skeletal muscle contractility is driven by the sarcomere, the fundamental unit of skeletal muscle contraction. From Wordnik.com. [Marketwire - Breaking News Releases]
Inhibition of calpain prevents muscle weakness and disruption of sarcomere structure during hindlimb suspension. From Wordnik.com. [SpaceRef Top Stories] Reference
The LAMP2 mutations cause sarcomere protein mutations which lead to the cardiomyopathy and the muscular dystrophy. From Wordnik.com. [Emaxhealth] Reference
This suggests that cTnIR193H has a dominant effect over TmA63V to shortening resting sarcomere lengths in intact cardiac myocytes. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
This torque has opposite effects on the thick and thin filaments because their fixed points are at opposite ends of the half sarcomere. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Muscles are designed to generate tension while shortening and accomplish this by using filaments that are polar within the half sarcomere. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
This movie shows Z-ward diffusion of a Type 2 weak binding myosin head as might occur during sarcomere shortening when the target zone moves. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
CK-2017357 is a fast skeletal muscle troponin activator and is the lead drug candidate from the company's skeletal sarcomere activator program. From Wordnik.com. [The Earth Times Online Newspaper] Reference
Now, researchers have discovered a protein that is the mainstay of the smallest muscular unit, the sarcomere, which contributes to a healthy heart. From Wordnik.com. [Gaea Times (by Simple Thoughts) Breaking News and incisive views 24/7] Reference
The strong activator cTnIR193H still exerted a dominant effect over the deactivator cTnCG159D to slow relaxation and shorten resting sarcomere length. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Yang J, Zhu J, Xu X (2009) Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere-membrane interaction, not sarcomere assembly. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Michele DE, Albayya FP, Metzger JM (1999) Thin filament protein dynamics in fully differentiated adult cardiac myocytes: toward a model of sarcomere maintenance. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Unloaded sarcomere shortening in intact adult rat cardiac myocytes at physiologic temperatures (37°C) was examined four days after dual adenoviral gene transfer. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Despite the varied natural histories of the inherited CM subtypes, the genetic basis of these diseases converge on one subcellular structure, the cardiac sarcomere. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Studies have shown that Tm incorporates from the pointed end to the Z-line of the sarcomere, while cTnI incorporation is stochastic and uniformly distributed along actin. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Baseline sarcomere lengths in G159D+R193H myocytes were significantly longer than those measured in R193H myocytes, but still significantly shorter than both WT and G159D. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
(B) Representative sarcomere shortening transients from A63V Tm. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
C) Summary of 75% sarcomere relaxation time and (D) Ca. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
E) Summary of baseline sarcomere lengths and (F) resting Ca. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Additional contractile parameters, including sarcomere shortening amplitude, were not different between groups (. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
B) Representative sarcomere shortening transients from G159D cTnC, R193H cTnI, and G159D cTnC + R193H cTnI transduced myocytes. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Diagram of a sarcomere. From Wordnik.com. [Illustrations. Fig. 376] Reference
Independent transition to shortened resting sarcomere lengths (. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Figure 28. 13A Contraction of a sarcomere 28-36. From Wordnik.com. [Recently Uploaded Slideshows] Reference
376 Diagram of a sarcomere. From Wordnik.com. [IV. Myology. 2. Development of the Muscles] Reference
C) Summary of 75% sarcomere relaxation time. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Representative sarcomere shortening traces (. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
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