The mutations affect a protein called gamma-secretase, which is involved in the build-up of protein plaques in the brains of people. From Wordnik.com. [Yahoo! News: Business - Opinion] Reference
The nicastrin protein is also a part of an enzyme called gamma-secretase, which is wedged in the cell’s membrane. From Wordnik.com. [Dallas Blog, Daily News, Dallas Politics, Opinion, and Commentary FrontBurner Blog D Magazine » Blog Archive » BIG NEWS ABOUT ALZHEIMER’S OUT OF UT SOUTHWESTERN] Reference
(Beta secretase was positively identified last year.). From Wordnik.com. [Alzheimer's Unlocking The Mystery] Reference
"Even a single enzyme such as gamma secretase has an effect on 20 proteins," he said. From Wordnik.com. [Lilly Halts Development] Reference
A few companies are still pursuing gamma blockers, but beta secretase now looks like a safer target for therapy. From Wordnik.com. [The Disappearing Mind] Reference
Occasionally, however, a pair of enzymes called beta and gamma secretase cleave APP in just the wrong places, leaving behind an insoluble A-beta fragment. From Wordnik.com. [The Disappearing Mind] Reference
"In the industry," says Dr. Ivan Lieberburg of Elan, "we're hoping that the beta-secretase inhibitors will have as much therapeutic potential as the statins.". From Wordnik.com. [The Disappearing Mind] Reference
We stumbled upon an observation that PS proteins in mammals can perform other functions besides the enzymatic ones, that is, outside its role as gamma secretase. From Wordnik.com. [2008 February - Telic Thoughts] Reference
After identifying APP, researchers determined that our bodies make at least three enzymes -- dubbed alpha, beta and gamma secretase -- that can cleave APP into shorter forms. From Wordnik.com. [Alzheimer's Unlocking The Mystery] Reference
Unlike alpha secretase, which clips an innocuous protein out of APP, the beta and gamma enzymes work together to produce a shorter, stickier protein called beta amyloid (A-beta). From Wordnik.com. [Alzheimer's Unlocking The Mystery] Reference
Modification of gamma secretase activity to decrease production of Aβ. From Wordnik.com. [Business Wire Travel News] Reference
But gamma secretase also plays an important role in everyday cell function. From Wordnik.com. [Yahoo! News: Business - Opinion] Reference
Notch versus the Proteasome: What is the Target of Gamma-secretase Inhibitor-I?. From Wordnik.com. [KOLO - HomePage - Headlines] Reference
Gamma secretase is also critical in the related processing of the Notch protein. From Wordnik.com. [WN.com - Articles related to DTI favors zero tariffs on cement, wheat] Reference
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. From Wordnik.com. [WebWire | Recent Headlines] Reference
Wolfe MS (2006) The gamma-secretase complex: membrane-embedded proteolytic ensemble. From Wordnik.com. [PLoS Biology: New Articles] Reference
Shih Ie M, Wang TL (2007) Notch signaling, gamma-secretase inhibitors, and cancer therapy. From Wordnik.com. [PLoS Biology: New Articles] Reference
"We are pleased to make public these data on our gamma secretase modulator, NGP 555," said. From Wordnik.com. [Business Wire Travel News] Reference
A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system. From Wordnik.com. [Health News from Medical News Today] Reference
This "toxic" molecule is generated by a stepwise process involving a pivotal enzyme, gamma secretase. From Wordnik.com. [Business Wire Travel News] Reference
Gamma secretase inhibitor is a class of drug currently being tested as a therapy for Alzheimer's Disease. From Wordnik.com. [Health News from Medical News Today] Reference
Her experiments suggest that blocking the protein hit by gamma secretase will kill brain cells over the long term. From Wordnik.com. [Forbes.com: News] Reference
Use of gamma secretase inhibitors may be associated with gastro-intestinal on-target side effects such as diarrhea. From Wordnik.com. [The Earth Times Online Newspaper] Reference
The closest equivalent to plasmepsin V in humans is a protein called beta secretase, but it's only distantly related. From Wordnik.com. [Media Newswire] Reference
The Y-secretase complex assumes a different shape and function according to the tissue in which the secretase is active. From Wordnik.com. [Sawf News - Fashions] Reference
The y-secretase complex - which cuts proteins at a specific place - plays a major role in the creation of these plaques. From Wordnik.com. [Sawf News - Fashions] Reference
"Modulation of beta and gamma secretase may provide novel therapeutic targets for the treatment of traumatic brain injury.". From Wordnik.com. [Health News from Medical News Today] Reference
"By using a gamma secretase inhibitor, we prevented much of secondary traumatic brain injury in mice in our experiments," he says. From Wordnik.com. [Science Blog - Science news straight from the source] Reference
With this discovery, the researchers are once again opening a way toward the development of medicines that deactivate Y-secretase. From Wordnik.com. [Sawf News - Fashions] Reference
The paper demonstrated that Neurogenetic Pharmaceuticals 'approach of gamma secretase modulation allows for selective reduction of Aβ. From Wordnik.com. [Business Wire Travel News] Reference
That is because the agents, known as gamma secretase inhibitors, are designed to prevent build-up of amyloid, a toxic peptide found in the brain. From Wordnik.com. [Science Blog - Science news straight from the source] Reference
They used a group of mice that were genetically altered so that they did not produce any beta secretase, which meant they were incapable of producing amyloid. From Wordnik.com. [Science Blog - Science news straight from the source] Reference
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