It has been known since the 1960s that one form of the malaria parasite - called the sporozoite - can wake up the immune system and help to protect against future infection. From Wordnik.com. [Newswise: Latest News] Reference
Anti-sporozoite vaccines, designed to prevent infection. From Wordnik.com. [Chapter 2] Reference
P. berghei sporozoite challenges for at least 19 months. From Wordnik.com. [Proceedings of the National Academy of Sciences current issue] Reference
+ T cells that mediate protection against Pb sporozoite challenge. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
We reduced it to 1% since the percentage of sporozoite gliding is still similar. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Goetz K, Matuschewski K (2008) A sporozoite asparagine-rich protein controls initiation of. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
At this concentration and time point no effect of EGCG on sporozoite viability was detected. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
− DC from Pb γ-spz-immunized mice induced protective immunity against sporozoite challenge. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Clearly, even higher EGCG concentrations may be necessary to achieve a sporozoite effect in vivo. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Other sporozoite or early liver-stage Ag specificities are possible, but they have not been tested. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
We next tested the effect of EGCG mediated inhibition of sporozoite gliding on liver cell infection. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
More information: Plasmodium sporozoite motility is modulated by the turnover of discrete adhesion sites. From Wordnik.com. [PhysOrg.com - latest science and technology news stories] Reference
+ T cell effector function following infectious sporozoite challenge occurs in the liver and is DC independent. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Sanaria's radiation attenuated sporozoite vaccine, Sanaria (TM) PfSPZ Vaccine, entered clinical trials in 2009. From Wordnik.com. [Medindia Health News] Reference
Plasmodium sporozoite movement patterns reveals a shift towards productive motility during salivary gland infection. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Garapaty S, Frevert U (2004) Kupffer and stellate cell proteoglycans mediate malaria sporozoite targeting to the liver. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
+ T cells to differentiate into the major effector T cells that confer protection against infectious sporozoite challenge. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
The high concentration necessary to inhibit motility and the late action on sporozoite survival along with the low bioavailability. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
We recently developed a methodology that should in principle allow visual screening for substances that inhibit sporozoite motility. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Digitonin synergistically increases the cytotoxicity of EGCG on sporozoite survival, but shows an additive effect on sporozoite motility. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
While digitonin showed an additive effect to EGCG on inhibiting motility, it showed a synergistic effect on inhibiting sporozoite survival. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
We next tested for a possible synergistic effect of EGCG together with digitonin on the inhibition of sporozoite motility after 40 minutes. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
These antigens are all exclusively expressed during the merozoite stage except for eba175 and msp4, which are also expressed in the sporozoite. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Sanaria has developed technologies and built a facility to manufacture a radiation attenuated sporozoite, is now being assessed in clinical trials. From Wordnik.com. [THE MEDICAL NEWS] Reference
Validating our visual screening procedure, we showed that sporozoite motility and liver cell infection is inhibited by EGCG at nontoxic concentrations. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Sub-samples of mosquitoes were taken from each trap to determine parity status, sporozoite infection and Anopheles gambiae complex sibling species identity. From Wordnik.com. [BioMed Central - Latest articles] Reference
"We needed to come up with another way to get the benefits of sporozoite immunization," says Charles M. Rice, head of the Laboratory of Virology and Infectious Disease. From Wordnik.com. [Newswise: Latest News] Reference
Glurp is unusual because it is expressed in a number of stages exposed to the human immune response including on the sporozoite, liver schizont, merozoite and gametocyte. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
An. stephensi blood meal, (H) an infected gut 8 days post-feed, (I) 10 day oocyst, (J) infected salivary gland dissected 18 days post-feed, (K) salivary gland sporozoite. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
If EGCG would bind to BSA and in addition on the sporozoite, a quenching effect of BSA could explain the observed high concentration of EGCG needed for inhibition of motility. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Plasmodium sporozoite motility and (ii) for possible effects of the secondary plant metabolite EGCG together with the saponin digitonin on cytotoxicity and inhibition of motility. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Indeed no difference of the effect of EGCG on sporozoite motility was found between media containing 1%, 0. 5% and 0. 25% BSA (. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
With our reporter parasite we were able reliably to image ookinetes and sporozoite motility in mosquito tissues (see Supplementary. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Plasmodium sporozoite motility and viability. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
40 minutes, while causing sporozoite death only after several hours. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
= 0.25) of EGCG with digitonin on the inhibition of sporozoite survival was shown. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
(1980) Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
(2007) Differential evidence of natural selection on two leading sporozoite stage malaria vaccine candidate antigens. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
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