Research on how sulindac sulfide reduces risk of colorectal cancer published in Cancer Letters; student body president. From Wordnik.com. [USATODAY.com - All-USA Academic second team] Reference
sulindac and sulindac sulfone protect normal lung cells against oxidative stress. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
The anticancer effect of sulindac alone has been reported to involve apoptotic death. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Effect of sulindac on the viability of cancer cells in response to oxidative stress. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
sulindac is a pro-drug that must be converted to the active COX-inhibitor, sulindac sulfide. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Ibuprofen, naproxen, indomethacin, and sulindac accounted for about 80\% of all NSAIDs used. From Wordnik.com. [MedPageToday.com - medical news plus CME for physicians] Reference
The anti-tumorigenic activity of sulindac against colon cancer may involve both COX inhibition. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Intracellular ROS levels in lung cancer cells pretreated with sulindac followed by oxidative stress. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Cell viability is expressed as % of control (cells not pretreated with sulindac or exposed to TBHP). From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Cell viability is expressed as % of control (cells not exposed to an NSAID, sulindac sulfone, or TBHP). From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Hooke K, Risley E, Shen T, Van Arman C (1977) Identification of the biologically active form of sulindac. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
As noted above, sulindac is a pro-drug that must be converted to the active COX-inhibitor, sulindac sulfide. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Similar results were obtained when sulindac was included during the 2 hr treatment with the oxidizing agent. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Human lung and colon cancer cell lines were preincubated in the presence or absence of sulindac for 48 hours. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Because of increased toxicity of sulindac sulfone a lower concentration (250 µM) was used for these experiments. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Brown SL, Kim JH (2004) Combined effect of arsenic trioxide and sulindac sulfide in A549 human lung cancer cells in vitro. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
The specimens were taken from precancerous lesions in animal models that were administered sulindac intervention for two weeks. From Wordnik.com. [UConn Advance Headlines] Reference
Each cancer cell line had a marked decrease in cell viability in the presence of TBHP following pretreatment with 500 µM sulindac. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Cells were then washed to remove the free sulindac prior to incubation for 2 hr with the indicated concentration of hydrogen peroxide. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
These results indicate that normal and cancer cells handle oxidative stress in different ways and sulindac can enhance this difference. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
It seems reasonable that sulindac may enhance the efficacy of any anticancer drug where the mechanism of action involves oxidative damage. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Cells were then washed to remove the free NSAID or sulindac sulfone prior to incubation for 2 hr with the indicated concentration of TBHP. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
For more than a decade, sulindac has also been of interest as a chemopreventive treatment for adenomatous colorectal polyps and colon cancer. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Figure 4 shows the effect of pretreating normal lung cells with sulindac or sulindac sulfone on cell viability after oxidative stress using TBHP. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
We have previously shown that conversion of sulindac to sulindac sulfide can be catalyzed by MsrA, a member of the methionine sulfoxide reductase. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Additionally, we wanted to determine whether normal cells and cancer cells responded in a similar way (s) after sulindac treatment and oxidative stress. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Gane P, Arico S, Codogno P, Ogier-Denis E (2001) Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Ignatenko NA, Casero RA Jr, Gerner EW (2003) Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Bottone F Jr, Martinez J, Collins J, Afshari C, Eling T (2003) Gene modulation by cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
The results described provide further evidence that a combination of sulindac and an oxidizing agent might have clinical therapeutic value in treating a variety of cancers. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
These results led to a limited clinical trial that showed promising potential of using topical application of sulindac and hydrogen peroxide for treatment of actinic keratoses. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
Figure 6B) or TBHP alone (Figure 6C), sulindac pretreatment of lung cancer cells followed by oxidative stress (. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
However, lung cancer cells that were pretreated with 500 µM sulindac followed by a 2 hr incubation with 80 µM TBHP (. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
(2009) Topical sulindac combined with hydrogen peroxide in the treatment of actinic kratoses. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
We can see this change occurring from sulindac. ". From Wordnik.com. [UConn Advance Headlines] Reference
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