Meanwhile, the pursuit of 6-MP, thioguanine, azathioprine and allopurinol had occupied 20 years. From Wordnik.com. [Nobel Lecture The Purine Path To Chemotherapy] Reference
We continued to synthesize derivatives of 6-MP and thioguanine and investigate structure-activity relationships (38-40). From Wordnik.com. [Nobel Lecture The Purine Path To Chemotherapy] Reference
This lead to the loss of antitumor activity, with the exception of the 2-amino-6-mercapto derivative, thioguanine, which we had previously found to have strong antimetabolic activity. From Wordnik.com. [Nobel Lecture The Purine Path To Chemotherapy] Reference
Our research was untargeted, and the line of inquiry we had begun in the 1940s yielded new drug therapies for malaria (pyrimethamine), leukemia (6-mercaptopurine and thioguanine), gout (allopurinol), organ transplantation. From Wordnik.com. [George H. Hitchings - Autobiography] Reference
Life-threatening ways and assuming have supported observed as linkages of thioguanine-induced granulocytopenia and thrombocytopenia. From Wordnik.com. [Wii-volution] Reference
However, the COG trial with 401 patients enrolled, showed that a thioguanine, procarbazine, lomustine and vincristine (TPCV) regimen was more effective than the CV regimen and resulted in a five-year event-free survival rate of nearly. From Wordnik.com. [WebWire | Recent Headlines] Reference
The study of 401 patients found that a regimen of thioguanine, procarbazine, lomustine and vincristine (TPCV) was more effective than a carboplatin and vincristine (VC) regimen and achieved a 5-year, event-free survival rate of almost 50 percent. From Wordnik.com. [Medlogs - Recent stories] Reference
(as well as thioguanine) are still used in the treatment of leukemia (Table II). From Wordnik.com. [Physiology or Medicine 1988 - Press Release] Reference
During 1950-51 they developed thioguanine and. From Wordnik.com. [Physiology or Medicine 1988 - Press Release] Reference
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