In its natural state, the aptamer binds with an enzyme called thrombin, which regulates blood clotting.    From Wordnik.com.  [University of Florida News] Reference

Scientists have known that a protein called thrombin plays an important role in clot formation as a potent activator of platelets.    From Wordnik.com. Reference

The newer drug works on one protein in the coagulation cascade called thrombin - "which is right at the blood clot, the one right at the end of this process," Sharma says.    From Wordnik.com.  [canada.com Top Stories] Reference

Factor VII and Factor X can substitute for thrombin 5,6.    From Wordnik.com.  [Behe vs Sea Squirts - The Panda's Thumb] Reference

Boehringer-Ingelheim's drug dabigatran blocks thrombin, another enzyme in clot formation.    From Wordnik.com.  [Race Is on for the Next Blood Thinner] Reference

Pradaxa acts by inhibiting thrombin, an enzyme in the blood that is involved in blood clotting.    From Wordnik.com.  [Drug to Prevent Stroke Is Approved] Reference

Another Factor Xa inhibitor,apixaban, is in trials as is a direct thrombin inhibitor,dabigatran.    From Wordnik.com.  [This time,new oral anticoagulants may well make it to the market] Reference

Despite knocking out thrombin, Factor X and Factor VI activate angiogenesis by alternate pathways.    From Wordnik.com.  [Behe vs Sea Squirts - The Panda's Thumb] Reference

In developing embryos, development of blood vessels angiogenesis depends on thrombin activating PAR-1 5.    From Wordnik.com.  [Behe vs Sea Squirts - The Panda's Thumb] Reference

Extracellular mediators in atherosclerosis and thrombosis: lessons from thrombin receptor knockout mice.    From Wordnik.com.  [Behe vs Sea Squirts - The Panda's Thumb] Reference

So the thrombin-like protein must be doing something different, yet it is capable of acting like thrombin.    From Wordnik.com.  [Behe vs Sea Squirts - The Panda's Thumb] Reference

The thrombin would immediately cut all the fibrin, causing a massive clot and the speedy death of the organism.    From Wordnik.com.  [The Politically Incorrect Guide to Darwinism and Intelligent Design Review: IC is not nice (Chapter 10) - The Panda's Thumb] Reference

Assume that we initially start with an organism that contains just a primitive version of thrombin and fibrinogen.    From Wordnik.com.  [The Politically Incorrect Guide to Darwinism and Intelligent Design Review: IC is not nice (Chapter 10) - The Panda's Thumb] Reference

A “primitive version” of thrombin would hardly chop up fibrinogen with the spectacular efficiency of our modern ones.    From Wordnik.com.  [The Politically Incorrect Guide to Darwinism and Intelligent Design Review: IC is not nice (Chapter 10) - The Panda's Thumb] Reference

Angiotech enters license, distribution and supply agreements for fibrin and thrombin technologies with Haemacure Corporation.    From Wordnik.com.  [Will NYTimes Science Stoop To Propaganda?] Reference

An experimental blood substitute is made from cow's blood, for instance, and a clotting medicine, thrombin, also derives from cattle.    From Wordnik.com.  [China's Role In Supply] Reference

While the short Factor XIII is able to be activated in the absence of thrombin, thrombin will also activate the short Factor XIII 11.    From Wordnik.com.  [Behe vs Sea Squirts - The Panda's Thumb] Reference

Furthermore, it is the amplification of thrombin activity by the cascade that results in spectacular fast clotting in advanced vertebrates.    From Wordnik.com.  [The Politically Incorrect Guide to Darwinism and Intelligent Design Review: IC is not nice (Chapter 10) - The Panda's Thumb] Reference

RECOTHROM®, a recombinant thrombin approved by the U.S.    From Wordnik.com.  [Business Wire Travel News] Reference

Cost of goods sold related to thrombin inventory 670 -- 670.    From Wordnik.com.  [News] Reference

Fifty-nine have made RECOTHROM the sole thrombin on the formulary.    From Wordnik.com.  [Biotech Sector and Stocks Analysis from Seeking Alpha] Reference

Description of the activity of thrombin and the activation of blood platelets.    From Wordnik.com.  [Sandwalk] Reference

However, this alone is not sufficient to account for thrombin-induced permeability.    From Wordnik.com.  [Journal of Biological Chemistry current issue] Reference

Fifty-two have added RECOTHROM to the formulary and thus have more than one thrombin product.    From Wordnik.com.  [Biotech Sector and Stocks Analysis from Seeking Alpha] Reference

The team measured endogenous thrombin potential (ETP) in stored blood samples of the remaining.    From Wordnik.com.  [BioSpace.com Featured News and Stories]

A protein that strongly promotes platelet activation through the integrin receptor is thrombin.    From Wordnik.com.  [EurekAlert! - Breaking News] Reference

• Significant difference in thrombin generation between women using oral and transdermal estrogens.    From Wordnik.com.  [BioSpace.com Featured News and Stories]

The PLoS ONE article stops with the definition of the chemistry of platelets 'two responses to thrombin.    From Wordnik.com.  [EurekAlert! - Breaking News] Reference

Cost of goods sold 5,619 4,497 20,690 17,002 Cost of goods sold related to thrombin inventory 670 -- 670.    From Wordnik.com.  [News] Reference

The corresponding protein expressed as a fusion with a N-terminal hexahistidine tag cleavable with thrombin.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

That's no way to support a drug pipeline. thrombin is competing against entrenched leader King Pharmaceuticals.    From Wordnik.com.  [Fool.com: The Motley Fool] Reference

Jeon OH, Kim DS (2009) Regulatory mechanism of matrix metalloprotease-2 enzymatic activity by factor Xa and thrombin.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Vorapaxar works through a new mechanism -- by blocking a receptor to thrombin, a protein highly involved in the clotting process.    From Wordnik.com.  [FinanzNachrichten.de: Aktuelle Nachrichten] Reference

ArterX was compared to a thrombin soaked gelatin-sponge hemostat in a superiority study to reduce or eliminate suture line bleeding.    From Wordnik.com.  [The Earth Times Online Newspaper] Reference

Hemostat products, that include our D-Stat Dry, D-Stat Flowable, and Thrombi-Gel products, all of which utilize thrombin to clot blood.    From Wordnik.com.  [pfblogs.org: The Ad-Free Personal Finance Blogs Aggregator (real estate blogs)] Reference

Factor Xa inhibitors interfere with formation of the fine threads of thrombin that bind the platelets together into a blood clot, he said.    From Wordnik.com.  [Health News from Medical News Today] Reference

Researchers in Scotland have shown that the novel particles can accurately detect thrombin, a biomarker for blood clots, in blood samples.    From Wordnik.com.  [Technology Review RSS Feeds] Reference