If a toxicant is lipid-soluble it readily penetrates cell membranes. From Wordnik.com. [Toxicity] Reference
Tissue affinity determines the degree of concentration of a toxicant. From Wordnik.com. [Distribution of toxicants in the body] Reference
Normally, the toxicant is only bound to the albumen for a relatively short time. From Wordnik.com. [Distribution of toxicants in the body] Reference
The primary sites for toxicant storage are adipose tissue, bone, liver and kidneys. From Wordnik.com. [Distribution of toxicants in the body] Reference
Initially, when a toxicant enters the blood plasma, it may be bound to plasma proteins. From Wordnik.com. [Distribution of toxicants in the body] Reference
A major determinant of whether or not a toxicant will damage cells is its lipid solubility. From Wordnik.com. [Toxicity] Reference
Environmental changes can alter fish habitat and toxicant accumulation from water and diet. From Wordnik.com. [Global change and contaminants in the Arctic] Reference
In this case, the blood levels of the toxicant "downstream" may be diminished or eliminated. From Wordnik.com. [Distribution of toxicants in the body] Reference
Organs that receive larger blood volumes can potentially accumulate more of a given toxicant. From Wordnik.com. [Distribution of toxicants in the body] Reference
Reproductive Toxicity involves toxicant damage to either the male or female reproductive system. From Wordnik.com. [Toxicity] Reference
The proportion of a toxicant moving by lymph is much smaller than that transported by the blood. From Wordnik.com. [Distribution of toxicants in the body] Reference
A systemic toxicant is one that affects the entire body or many organs rather than a specific site. From Wordnik.com. [Toxicology] Reference
Ability of environmental toxicant trichloroethylene to promote immune pathology is strain-specific. From Wordnik.com. [The Autoimmune Epidemic] Reference
Vegetables irrigated with perchlorate-laden water take up the toxicant, causing concern for contamination. From Wordnik.com. [Fate and effects of perchlorate] Reference
In addition, the body burden for a toxicant can be estimated from knowledge of the VD by using the formula. From Wordnik.com. [Distribution of toxicants in the body] Reference
The volume of distribution may provide useful estimates as to how extensive the toxicant is distributed in the body. From Wordnik.com. [Distribution of toxicants in the body] Reference
Distribution of a chemical to body cells and tissues requires that the toxicant penetrate a series of cell membranes. From Wordnik.com. [Distribution of toxicants in the body] Reference
To exert an effect on internal organs a toxicant must be absorbed, although such local toxicity as irritation, may occur. From Wordnik.com. [Absorption of toxicants] Reference
If the toxicant gains entrance into the blood plasma, it travels along with the blood, either in a bound or unbound form. From Wordnik.com. [Distribution of toxicants in the body] Reference
Also, using this information, they determined the total daily intake of the toxicant for each age group per day (Table 2). From Wordnik.com. [Fate and effects of perchlorate] Reference
This can result from toxicant exposure to either parent before conception or to the mother and her developing embryo-fetus. From Wordnik.com. [Toxicity] Reference
Toxicologists determine the VD of a toxicant in order to know how extensively a toxicant is distributed in the body fluids. From Wordnik.com. [Distribution of toxicants in the body] Reference
Disposition models have been derived to describe how a toxicant moves within the body with time (also known as kinetic models). From Wordnik.com. [Distribution of toxicants in the body] Reference
This is a form of storage since the toxicant, while bound to the protein, does not contribute to the chemical's toxic potential. From Wordnik.com. [Distribution of toxicants in the body] Reference
The plasma level of a xenobiotic is important since it generally reflects the concentration of the toxicant at the site of action. From Wordnik.com. [Distribution of toxicants in the body] Reference
Some toxicants may bind to these plasma proteins (especially albumin), which "removes" the toxicant from potential cell interaction. From Wordnik.com. [Distribution of toxicants in the body] Reference
The toxicant is thus distributed to various organs of the body before it goes to the liver, and not subject to this first-pass effect. From Wordnik.com. [Distribution of toxicants in the body] Reference
A toxicant that enters the lymph of the intestinal tract will not go to the liver first but will slowly enter the systemic circulation. From Wordnik.com. [Distribution of toxicants in the body] Reference
The passive diffusion of the toxicant into or out of these body fluids will be determined mainly by the toxicant's concentration gradient. From Wordnik.com. [Distribution of toxicants in the body] Reference
Suspected endocrine disrupter and reproductive toxicant. From Wordnik.com. [CBC | Top Stories News] Reference
Suspected endocrine disrupter and reproductive toxicant (cyclotetrasiloxane). From Wordnik.com. [CBC | Top Stories News] Reference
A suspected endocrine disrupter and reproductive toxicant that's also harmful to fish and wildlife. From Wordnik.com. [canada.com Top Stories] Reference
Sorbitol, a suspected gastrointestinal and liver toxicant. From Wordnik.com. [LA IMC] Reference
Phenoxyethanol (antifreeze), a suspected developmental and reproductive toxicant. From Wordnik.com. [LA IMC] Reference
It has been listed on California’s Proposition 65 list as a carcinogen and reproductive toxicant. From Wordnik.com. [John DeCock: A New Chapter In The Erin Brockovich/Hexavalent Chromium Story] Reference
An immunotoxicant and respiratory toxicant. From Wordnik.com. [Kevin Grandia: What the Frack: is pumping glass cleaner into the earth okay?] Reference
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