In each of the 19 pathways for the generation of chiral amino acids, the stereochemistry at the α-carbon atom is established by a transamination reaction that involves pyridoxal phosphate. From Wordnik.com. [Are Stereochemical Explanations Causally Sufficient?] Reference
It is involved in many reactions, primarily transamination. From Wordnik.com. [Straight to the Bar - Blogs] Reference
The metabolite accumulating in ssadh plants which is linked to the production of ROIs might thus be produced downstream of the GABA-T transamination step. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
It is thought that the antiepileptic activity of VPA results from a combination of its influence on a number of targets in the central nervous system including inhibition of GABA transamination, reduction of NMDA-mediated neuronal excitation, inhibition of histone deacetylases (HDACs) and glycogen synthase kinase (GSK) -3, and blockade of voltage-gated sodium and T-type calcium channels. From Wordnik.com. [PLoS ONE Alerts: New Articles] Reference
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