Treatment of X-linked Severe Combined Immunodeficiency (X-SCID) by the in utero transplantation of paternal bone marrow.    From Wordnik.com.  [Fetal Stem Cell Transplantation, In Utero Stemm Cell Publications] Reference

The London hospital said 18-month-old Rhys Evans had been cured of the fatal genetic condition X-linked Severe Combined Immunodeficiency Disease X-SCID, commonly known as “baby in the bubble” syndrome.    From Wordnik.com.  [‘Bubble Boy’ Cured in Gene Therapy Breakthrough | Impact Lab] Reference

Both this child and another who had developed a similar condition in August 2002 had been successfully treated by gene therapy for X-linked severe combined immunodeficiency disease (X-SCID), also known as "bubble baby syndrome.".    From Wordnik.com.  [Gene Therapy Novel Therapeutic Branch of Modern Medicine] Reference

Peripheral blood profiles of Il2rg-deficient (X-SCID) rats.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Table S3 to characterize the immunodeficient phenotypes of the X-SCID rats.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Differential counts of the white blood cells of Il2rg-deficient (X-SCID) rats.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In addition, the X-SCID rats that were established in this study will be valuable.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The thymus of the X-SCID rat was severely hypoplastic and consisted of an epithelial cell sheet.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Differential counts of WBCs showed a dramatic decrease in leukocytes in the X-SCID rats (Table S5).    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

IL-2 receptor deficiency is responsible for the x-linked severe combined immunodeficiency syndrome (X-SCID).    From Wordnik.com.  [Citizendium, the Citizens' Compendium - Recent changes [en]] Reference

Flow cytometric analysis of bone marrow lymphocyte cells (a) and spleen lymphocyte cells (b) from five-week-old F344 and X-SCID rats.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Gross and microscopic analyses at five weeks of age showed that the X-SCID rats underwent abnormal lymphoid development as depicted in.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In addition, the gene is involved in the X-linked form of severe combined immunodeficiency (X-SCID), one of the most common forms of human SCID.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Gene therapy has already been successfully deployed to treat children with X-SCID - a life-threatening immune deficiency also known as "boy in the bubble syndrome".    From Wordnik.com.  [BBC News | News Front Page | World Edition] Reference

RT-PCR and Western blot assays was performed on these G1 rats and the results showed a complete loss of expression of the Abnormal lymphoid development in X-SCID rats.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

These immunodeficient phenotypes of the X-SCID rats were very similar to those of the previously reported X-SCID mice and were characterized by a nearly complete lack of T-cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In addition, the X-SCID rats that were established in this study will be valuable in vivo tools for evaluating drug treatment or gene therapy as well as model systems for examining the treatment of xenotransplanted malignancies.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The X-SCID rats established in this study provide not only a valuable in vivo model for evaluating drug treatment or gene therapy approaches, but also a system for assaying novel anticarcinogenic effects on transplanted malignancies.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In the X-SCID spleen, the white pulp was virtually devoid of lymphocytes and the red pulp was occupied by a variety of myeloid elements. (h) Dot plots representing CD3, CD45RA and CD161a for differentiation of T -, B - and NK cell sub-populations, and CD3, CD4 and CD8 for demarcation of T-cell sub-populations in peripheral blood lymphocyte cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

A major motivation for performing this experiment was the observation that although SCID mouse animal models are the most commonly used in research on drug development, an X-SCID immunodeficient rat model would complement mouse models through the additional advantage of being employed for testing the pharmacodynamics and toxicity of potential therapeutic compounds.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

(f, g) Histological analysis of the spleen of X-SCID (X100) and F344 (X100) rats.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Generation of Knockout Rats with X-Linked Severe Combined Immunodeficiency (X-SCID) Using Zinc-Finger Nucleases.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Generation of Knockout Rats with X-Linked Severe Combined Immunodeficiency (X-SCID) Using Zinc-Finger Nucleases.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

(a) Growth curve of tumor development after subcutaneous injection of A2780 human ovarian cancer cells in F344 and X-SCID rats.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

All X-SCID rats developed tumors within 14 days after injection of the cells (6/6.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Il2rg) locus, where orthologous human and mouse mutations cause X-linked severe combined immune deficiency (X-SCID).    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Okay, so retroviral gene therapy has been tried before, and though it cured the kids of X-SCID, some of them ended up getting leukemia instead (funny how MLV causes causes 'weird vague symptoms in CFS patients. isnt that weird.    From Wordnik.com.  [ScienceBlogs Channel : Life Science] Reference

(a) Photograph of five week-old male X-SCID (Il2rg −.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Il2rgttm1Kyo X-SCID rats are deposited at the National Bio Resource Project for the Rat in Japan (.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

/Y) and F344 (+ /Y) rats. (b) Thymus of X-SCID and F344 rats. (c) Spleen of X-SCID and F344 rats. (d, e) Histological analysis of the thymus of X-SCID (X40) and F344 (X40) rats.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference