Superacids are so strong that they can protonate such extremely weak bases as the alkanes, as was shown by Olah and independently by H. Hogeveen. From Wordnik.com. [Press Release: The 1994 Nobel Prize in Chemistry] Reference
Glu431 is conserved among GMPRs, suggesting that the Thr321 pathway has a crucial function in this reaction, perhaps operating in the reverse to protonate the ammonia leaving group. From Wordnik.com. [PLoS Biology: New Articles] Reference
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