Previously, Teyton and Wilson labs had determined the structure of a "diabetogenic" MHC molecule and found that mutations to position 57 caused only subtle changes.    From Wordnik.com.  [EurekAlert! - Breaking News] Reference

I am mistakenly supposed to have described a diabetogenic hormone.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

The diabetogenic effect of the hypophysis is dependent on the liver.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

The hypophysis of all vertebrates has this diabetogenic effect on animals of its own and other species.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

When there is not enough insulin, sugar is not utilized but excreted, i.e. there is a diabetogenic effect.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

The diabetogenic effect of the hypophysis was first observed in animals in which both the hypophysis and the pancreas had been removed.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

A recent study confirmed this finding and suggested that the “thin fat phenotype” in neonates persisted in childhood and could be a forerunner of the diabetogenic adult phenotype.    From Wordnik.com.  [Diabetes Time Bomb] Reference

On the other hand, destruction of the diencephalon or removal of the whole brain, or extirpation of the kidneys, the adrenals, the thyroid, the lungs and all the digestive tract do not prevent the diabetogenic effect.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

The experiments of Long show that the adrenocorticotrophic hormone of the hypophysis by releasing corticoadrenal hormones, plays a part in the diabetogenic effect; but my own experiments prove there is a hypophyseal diabetogenic action which takes place when there are no adrenals.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

In the toad and in the dog, adrenalectomy diminishes but does not suppress the diabetogenic effect of the anterior lobe extract, which can be obtained in adrenalectomized dogs, in which the pancreas has been surgically reduced, and which are kept alive by treatment with desoxycorticosterone and salt or even with sodium chloride alone.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

Extrapancreatic: factors are demonstrated by: (1) the diabetogenic effect obtained in pancreatectomized hypophysectomized animals; (2) the increase in the severity of diabetes in pancreatectomized dogs treated with anterohypophyseal extract; (3) the increase in resistance to insulin which precedes and accompanies hypophyseal diabetes; (4) the fact that hyperglycemia and diabetes occur before that there are visible lesions in the beta cells of the islets, and before insulin secretion diminishes.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

Epidemiologic evidence of diabetogenic effect of arsenic.    From Wordnik.com.  [WordPress.com News] Reference

Recipients only receiving diabetogenic splenocytes were regarded as positive controls.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

R-1 like cells in a Th2-like environment, and (3) their anti-diabetogenic phenotype is CD3.    From Wordnik.com.  [Elites TV] Reference

Accumulating evidence indicates that many GAD-specific responses may be protective and not diabetogenic.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Dalberg U, Markholst H, Hornum L (2007) Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Cadmium is a widespread environmental pollutant that accumulates in the pancreas and exerts diabetogenic effects in animals.    From Wordnik.com.  [WordPress.com News] Reference

The electrostatic potential within the peptide binding pocket exerts a strong influence on diabetogenic epitopes with basic residues.    From Wordnik.com.  [BioMed Central - Latest articles] Reference

Weight loss in abdominally obese patients is associated with selective mobilization of diabetogenic and atherogenic visceral adipose tissue.    From Wordnik.com.  [Recently Uploaded Slideshows] Reference

+CD25+ T cells expressing CD103 and granzyme B, and most importantly, by the ability of this regulatory cell population to keep diabetogenic cells under control.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

+CD25+ regulatory T cells may play an important role in the control of diabetogenic cells and prevention of diabetes development in CFA-treated disease-free NOD mice.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In the nonobese diabetic (NOD) mouse model of type 1 diabetes, we have identified the peptide WE14 from chromogranin A (ChgA) as the antigen for highly diabetogenic CD4.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

Epitope-expanded CD4+CD25+ T cells were purified as described above and injected intravenously (at different cell numbers, as indicated) into 4-8 wk old NOD. scid mice along with diabetogenic splenocytes isolated from acutely diabetic NOD mice.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Because these abnormalities increase the risk of cardiovascular disease (CVD) and type 2 diabetes, numerous consensus groups have attempted to provide guidelines to identify patients in clinical practice with these atherogenic/diabetogenic metabolic abnormalities.    From Wordnik.com.  [WN.com - Articles related to Scientists identify risks of hypertension in young adults] Reference

T cell responses against GAD65 can be detected in young NOD mice and in humans at risk of type 1 diabetes cell-specific suppression of GAD65 expression in antisense GAD65 transgenic NOD mice leads to complete prevention of type 1 diabetes and blocks the generation of diabetogenic T cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In addition to Teyton, Wilson, Corper, and Yoshida (currently assistant professor at Meijo University, Japan), the authors of the paper, "The diabetogenic murine MHC class II molecule I-Ag7 is endowed with a switch which modulates TCR affinity," include Rana Herro of Scripps Research and Bana Jabri of the University of Chicago.    From Wordnik.com.  [EurekAlert! - Breaking News] Reference

Later the diabetogenic effect was also demonstrated in dogs with a surgically reduced pancreas (Houssay.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference

+CD25+ T cells to suppress diabetes when co-transferred with diabetogenic T cells (1×10.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

A diabetogenic hormone.    From Wordnik.com.  [Bernardo Houssay - Nobel Lecture] Reference